COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Title:

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Document Type and Number:

WIPO Patent Application WO/2016/127859

Kind Code:

A1

Abstract:

Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.

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Inventors:

ZHANG YINGJUN (CN)
LUO HUICHAO (CN)
REN QINGYUN (CN)
XIONG ZHIMIN (CN)
LIU YANG (CN)
LEI YIBO (CN)
XIONG JINFENG (CN)
ZHANG JIANCUN (CN)

Application Number:

PCT/CN2016/073156

Publication Date:

August 18, 2016

Filing Date:

February 02, 2016

Export Citation:

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Assignee:

SUNSHINE LAKE PHARMA CO LTD (CN)

International Classes:

C07D519/00; A61K31/395; A61P1/16; A61P31/14

Domestic Patent References:

WO2010088394A1

2010-08-05

Other References:

KAZMIERSKI, W. M. ET AL.: "Discovery of Novel Urea-Based Hepatitis C Protease Inhibitors with High Potency against Protease-Inhibitor-Resistant Mutants", J. MED. CHEM., vol. 55, no. 7, 3 April 2012 (2012-04-03)

Attorney, Agent or Firm:

TSINGYIHUA INTELLECTUAL PROPERTY LLC (Trade Building Zhaolanyuan,Tsinghua University, Qinghuayuan, Haidian District, Beijing 4, CN)

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