Title:
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/160672
Kind Code:
A1
Abstract:
The present disclosure provides LPA antagonists of formula I, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating LPA-associated diseases, disorders, and conditions.
Inventors:
HUANG WEI (CN)
LEI HUI (CN)
XU ZHONGMIAO (CN)
ZHANG HAIZHEN (CN)
ZHANG QIONG (CN)
LEI HUI (CN)
XU ZHONGMIAO (CN)
ZHANG HAIZHEN (CN)
ZHANG QIONG (CN)
Application Number:
PCT/CN2023/078288
Publication Date:
August 31, 2023
Filing Date:
February 25, 2023
Export Citation:
Assignee:
LHOTSE BIO INC (US)
HUANG WEI (CN)
HUANG WEI (CN)
International Classes:
A61P11/00; A61K31/192; A61K31/196; A61K31/351; A61K31/36; A61K31/397; A61K31/4433; A61P35/00; A61P37/00; C07C59/13; C07D205/04; C07D211/66; C07D213/65; C07D309/14; C07D317/50; C07D401/12; C07D405/12; C07D407/12
Domestic Patent References:
| WO2019246109A1 | 2019-12-26 | |||
| WO2003026587A2 | 2003-04-03 |
Foreign References:
| EP3912975A1 | 2021-11-24 |
Other References:
FOSTER: "Deuterium Isotope Effects in Studies of Drug Metabolism", TRENDS PHARMACOL. SCI., vol. 5, no. 12, 1984, pages 524 - 527, XP025943358, DOI: 10.1016/0165-6147(84)90534-0
"Remington: The Science and Practice of Pharmacy", 2012, LIPPINCOTT WILLIAMS & WILKINS
"Pharmaceutical Preformulation and Formulation", 2009, THE PHARMACEUTICAL PRESS AND THE AMERICAN PHARMACEUTICAL ASSOCIATION
"Handbook of Pharmaceutical Additives", 2007, GOWER PUBLISHING COMPANY
YAMADA, CANCER SCI., vol. 99, no. 8, 2008, pages 1603 - 1610
BOUCHARABA ET AL., J CLIN. INVEST., vol. 114, no. 12, 2004, pages 1714 - 1725
BOUCHARABA ET AL., PROC. NATL. ACAD. SCI., vol. 103, no. 25, 2006, pages 9643 - 9648
T. W. GREENEG. M. WUTS: "Pharmaceutical Dosage Forms: Parenteral Medications", vol. 1-2, 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY, AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", 2001, JOHN WILEY, AND SONS
"Remington: The Science and Practice of Pharmacy", 2012, LIPPINCOTT WILLIAMS & WILKINS
"Pharmaceutical Preformulation and Formulation", 2009, THE PHARMACEUTICAL PRESS AND THE AMERICAN PHARMACEUTICAL ASSOCIATION
"Handbook of Pharmaceutical Additives", 2007, GOWER PUBLISHING COMPANY
YAMADA, CANCER SCI., vol. 99, no. 8, 2008, pages 1603 - 1610
BOUCHARABA ET AL., J CLIN. INVEST., vol. 114, no. 12, 2004, pages 1714 - 1725
BOUCHARABA ET AL., PROC. NATL. ACAD. SCI., vol. 103, no. 25, 2006, pages 9643 - 9648
T. W. GREENEG. M. WUTS: "Pharmaceutical Dosage Forms: Parenteral Medications", vol. 1-2, 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY, AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", 2001, JOHN WILEY, AND SONS
Attorney, Agent or Firm:
WU , FENG & ZHANG (CN)
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