Title:
INDUCIBLE MATURE LIVER CELL AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/160671
Kind Code:
A1
Abstract:
The present invention relates to a composition for preparing and inducing an inducible mature liver cell, a method for preparing an inducible mature liver cell, and a produced inducible mature liver cell.
Inventors:
DING SHENG (CN)
HAO JIE (CN)
MA TIANHUA (CN)
HAO JIE (CN)
MA TIANHUA (CN)
Application Number:
PCT/CN2023/078284
Publication Date:
August 31, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C12N5/0775; C12N5/071
Foreign References:
| US20180055887A1 | 2018-03-01 | |||
| US20190345442A1 | 2019-11-14 | |||
| AU3521501A | 2001-07-05 | |||
| JP2021143194A | 2021-09-24 |
Other References:
LI ZHONGWEN, WU JUN, WANG LEI, HAN WEIFANG, YU JUAN, LIU XIN, WANG YUKAI, ZHANG YING, FENG GUIHAI, LI WEI, STACEY GLYN NIGEL, GU Q: "Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions", CELL DEATH & DISEASE, vol. 10, no. 10, 10 October 2019 (2019-10-10), XP093087103, DOI: 10.1038/s41419-019-1967-5
YUANYUAN DU, JINLIN WANG, JUN JIA, NAN SONG, CHENGANG XIANG, JUN XU, ZHIYUAN HOU, XIAOHUA SU, BEI LIU, TAO JIANG, DONGXIN ZHAO, YI: "Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming", CELL STEM CELL, ELSEVIER, CELL PRESS, vol. 14, no. 3, 1 March 2014 (2014-03-01), pages 394 - 403, XP055194340, ISSN: 19345909, DOI: 10.1016/j.stem.2014.01.008
XIE BINGQING; SUN DA; DU YUANYUAN; JIA JUN; SUN SHICHENG; XU JUN; LIU YIFANG; XIANG CHENGANG; CHEN SITONG; XIE HUANGFAN; WANG QIMI: "A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 29, no. 9, 3 July 2019 (2019-07-03), Singapore , pages 696 - 710, XP036917071, ISSN: 1001-0602, DOI: 10.1038/s41422-019-0196-x
YUANYUAN DU, JINLIN WANG, JUN JIA, NAN SONG, CHENGANG XIANG, JUN XU, ZHIYUAN HOU, XIAOHUA SU, BEI LIU, TAO JIANG, DONGXIN ZHAO, YI: "Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming", CELL STEM CELL, ELSEVIER, CELL PRESS, vol. 14, no. 3, 1 March 2014 (2014-03-01), pages 394 - 403, XP055194340, ISSN: 19345909, DOI: 10.1016/j.stem.2014.01.008
XIE BINGQING; SUN DA; DU YUANYUAN; JIA JUN; SUN SHICHENG; XU JUN; LIU YIFANG; XIANG CHENGANG; CHEN SITONG; XIE HUANGFAN; WANG QIMI: "A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 29, no. 9, 3 July 2019 (2019-07-03), Singapore , pages 696 - 710, XP036917071, ISSN: 1001-0602, DOI: 10.1038/s41422-019-0196-x
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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