Title:
COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/078120
Kind Code:
A1
Abstract:
Provided herein are a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.
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Inventors:
ZHU TINGYING (CN)
BLAQUIERE NICOLE (US)
HUANG RICHARD (US)
KIRRANE THOMAS (US)
KORDIKOWSKI ANDREAS (CH)
MATA ANNE-CATHERINE (US)
SARKO CHRISTOPHER (US)
TAFT BENJAMIN (US)
WALDRON GRACE (US)
YOKOKAWA FUMIAKI (US)
BLAQUIERE NICOLE (US)
HUANG RICHARD (US)
KIRRANE THOMAS (US)
KORDIKOWSKI ANDREAS (CH)
MATA ANNE-CATHERINE (US)
SARKO CHRISTOPHER (US)
TAFT BENJAMIN (US)
WALDRON GRACE (US)
YOKOKAWA FUMIAKI (US)
Application Number:
PCT/CN2020/122217
Publication Date:
April 29, 2021
Filing Date:
October 20, 2020
Export Citation:
Assignee:
NOVARTIS AG (CH)
ZHU TINGYING (CN)
ZHU TINGYING (CN)
International Classes:
C07D513/04; A61K31/433; A61P33/06; C07D519/00
Domestic Patent References:
| WO2012020215A1 | 2012-02-16 | |||
| WO2012020217A1 | 2012-02-16 | |||
| WO2009040552A2 | 2009-04-02 | |||
| WO2014078813A1 | 2014-05-22 | |||
| WO2010012345A1 | 2010-02-04 |
Other References:
EMILY R. DERBYSHIRE, VANESSA ZUZARTE-LUÍS, ANDREIA D. MAGALHÃES, NOBUTAKA KATO, PAUL C. SANSCHAGRIN, JINHUA WANG, WENJUN ZHOU, CHA: "Chemical Interrogation of the Malaria Kinome.", CHEMBIOCHEM, vol. 15, no. 13, 5 September 2014 (2014-09-05), pages 1920 - 1930, XP055431920, ISSN: 1439-4227, DOI: 10.1002/cbic.201400025
ARANG NADIA, KAIN HEATHER S., GLENNON ELIZABETH K., BELLO THOMAS, DUDGEON DENALI R., WALTER EMILY N. F., GUJRAL TARANJIT S., KAUSH: "Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles.", NATURE COMMUNICATIONS, vol. 8, 1232, 1 November 2017 (2017-11-01), pages 1 - 9, XP055805813, DOI: 10.1038/s41467-017-01345-2
See also references of EP 4048678A4
ARANG NADIA, KAIN HEATHER S., GLENNON ELIZABETH K., BELLO THOMAS, DUDGEON DENALI R., WALTER EMILY N. F., GUJRAL TARANJIT S., KAUSH: "Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles.", NATURE COMMUNICATIONS, vol. 8, 1232, 1 November 2017 (2017-11-01), pages 1 - 9, XP055805813, DOI: 10.1038/s41467-017-01345-2
See also references of EP 4048678A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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