Title:
COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM
Document Type and Number:
WIPO Patent Application WO/2001/053267
Kind Code:
A1
Abstract:
Pharmaceutical compositions exhibiting thrombopoietin receptor agonism, which contain as the active ingredient compounds of the general formula (I): X?1¿-Y?1¿-Z?1¿-W?1¿ prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them wherein X?1¿ is optionally substituted aryl, optionally substituted heteroaryl, or the like; Y?1¿ is -NR?A¿CO-(CH¿2?)¿0-2?- (wherein R?A¿ is hydrogen or the like) or the like; Z?1¿ is optionally substituted phenylene or the like; and W?1¿ is a group of the general formula (II): (II) (wherein R?1¿, R?2¿, R?3¿ and R?4¿ are each independently hydrogen, optionally substituted lower alkyl, or the like; and the broken line represents the presence or absence of a bond), or the like.
Inventors:
TAKEMOTO HIROSHI (JP)
SHIOTA TAKESHI (JP)
TAKAYAMA MASAMI (JP)
SHIOTA TAKESHI (JP)
TAKAYAMA MASAMI (JP)
Application Number:
PCT/JP2001/000411
Publication Date:
July 26, 2001
Filing Date:
January 23, 2001
Export Citation:
Assignee:
SHIONOGI & CO (JP)
TAKEMOTO HIROSHI (JP)
SHIOTA TAKESHI (JP)
TAKAYAMA MASAMI (JP)
TAKEMOTO HIROSHI (JP)
SHIOTA TAKESHI (JP)
TAKAYAMA MASAMI (JP)
International Classes:
A61K31/426; A61K31/427; A61K31/4439; A61K31/5377; A61P7/02; A61P43/00; C07D231/40; C07D233/88; C07D249/14; C07D277/46; C07D277/82; C07D285/16; C07D285/18; C07D333/38; C07D417/04; C07D417/14; (IPC1-7): C07D231/40; C07D231/52; C07D233/88; C07D239/14; C07D277/46; C07D277/60; C07D285/08; C07D285/12; C07D333/38; C07D417/04; C07D417/12; C07D213/73; A61K31/381; A61K31/415; A61K31/4168; A61K31/4196; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K31/5377; A61P43/00; A61P7/02
Domestic Patent References:
| WO1994004516A1 | 1994-03-03 |
Foreign References:
| JPH10287634A | 1998-10-27 | |||
| JPH07112975A | 1995-05-02 | |||
| EP0295656A1 | 1988-12-21 | |||
| EP0719115A1 | 1996-07-03 |
Other References:
See also references of EP 1253142A4
None
None
Attorney, Agent or Firm:
Yamauchi, Hideaki c/o Shionogi & Co. (Ltd. Intellectual Property Department 12-4
Sagisu 5-chom, Fukushima-ku Osaka-shi Osaka, JP)
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