Title:
COMPOUNDS FOR NON-INVASIVE MEASUREMENT OF AGGREGATES OF AMYLOID PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2010/092111
Kind Code:
A3
Abstract:
The invention relates to the provision of compounds, methods for producing them, and their use for imaging and quantification of aggregates of β-amyloid peptides in vivo. In a preferred aspect of the invention, a tracer is administered to humans and displays enrichment in body parts that are containing aggregates of amyloid peptides. Tracers of the invention can be used for non-invasive depiction and quantification of aggregates of β-amyloid peptides in humans affected with diseases that are characterized in the generation of such aggregates.
Inventors:
GJERMUND HENRIKSEN (DE)
HOOSHYAR YOUSEFI BEHROOZ (DE)
WESTER HANS-JUERGEN (DE)
HOOSHYAR YOUSEFI BEHROOZ (DE)
WESTER HANS-JUERGEN (DE)
Application Number:
PCT/EP2010/051704
Publication Date:
November 04, 2010
Filing Date:
February 11, 2010
Export Citation:
Assignee:
UNIV MUENCHEN TECH (DE)
GJERMUND HENRIKSEN (DE)
HOOSHYAR YOUSEFI BEHROOZ (DE)
WESTER HANS-JUERGEN (DE)
GJERMUND HENRIKSEN (DE)
HOOSHYAR YOUSEFI BEHROOZ (DE)
WESTER HANS-JUERGEN (DE)
International Classes:
A61K51/04; C07D277/62; C07D471/04; C07D487/04; C07D513/04; A61K101/00; A61K101/02
Domestic Patent References:
| WO2008118122A2 | 2008-10-02 | |||
| WO2002014321A1 | 2002-02-21 | |||
| WO1998006724A1 | 1998-02-19 | |||
| WO2010011964A2 | 2010-01-28 |
Foreign References:
| JP2001048786A | 2001-02-20 | |||
| EP0605295A1 | 1994-07-06 |
Attorney, Agent or Firm:
WICHMANN, Hendrik (Schweigerstrasse 2, München, DE)
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