Title:
COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND beta-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE
Document Type and Number:
WIPO Patent Application WO2005016885
Kind Code:
A3
Abstract:
The present invention provides compounds possessing inhibitory activity against beta-adrenergic receptors and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated, and for treating hypertension, cardiovascular disease, congestive heart failure, myocardial ischemia, cardiomyopathies, stroke or epilepsy.
Inventors:
HAMILTON GREGORY S (US)
Application Number:
PCT/US2004/026326
Publication Date:
June 23, 2005
Filing Date:
August 16, 2004
Export Citation:
Assignee:
ARTESIAN THERAPEUTICS INC (US)
HAMILTON GREGORY S (US)
HAMILTON GREGORY S (US)
International Classes:
A61K31/4422; A61P9/00; C07D211/90; C07D401/12; (IPC1-7): C07D211/90; A61K31/4422; A61P9/00; C07D401/12
Domestic Patent References:
| WO2004033444A1 | 2004-04-22 | |||
| WO2003062201A1 | 2003-07-31 |
Foreign References:
| EP1108710A1 | 2001-06-20 | |||
| DE2228363A1 | 1974-01-03 | |||
| US4500527A | 1985-02-19 | |||
| US20030055066A1 | 2003-03-20 | |||
| EP0488345A1 | 1992-06-03 | |||
| EP1260232A1 | 2002-11-27 | |||
| EP0260675A1 | 1988-03-23 |
Other References:
SHIM, YOUNG KEY ET AL: "Synthesis of combination compounds of dihydropyridine and m-blockers", BULLETIN OF THE KOREAN CHEMICAL SOCIETY , 11(3), 181-3 CODEN: BKCSDE; ISSN: 0253-2964, 1990, XP002311945
LIANG, JHY-CHONG ET AL: "The new generation dihydropyridine type calcium blockers, bearing 4-phenyl oxypropanolamine, display .alpha.-/.beta.-Adrenoceptor antagonist and long-Acting antihypertensive activities", BIOORGANIC & MEDICINAL CHEMISTRY , 10(3), 719-730 CODEN: BMECEP; ISSN: 0968-0896, 2002, XP002311944
SHEU M M ET AL.: "Vanidilol: A vanilloid-type vasorelaxant and ocular hypotensive beta-arenoreceptor with partial beta-2-agonist activity", PHARMACOLOGY, vol. 54, no. 4, April 1997 (1997-04-01), pages 211 - 224, XP009042020
LIANG, JHY-CHONG ET AL: "The new generation dihydropyridine type calcium blockers, bearing 4-phenyl oxypropanolamine, display .alpha.-/.beta.-Adrenoceptor antagonist and long-Acting antihypertensive activities", BIOORGANIC & MEDICINAL CHEMISTRY , 10(3), 719-730 CODEN: BMECEP; ISSN: 0968-0896, 2002, XP002311944
SHEU M M ET AL.: "Vanidilol: A vanilloid-type vasorelaxant and ocular hypotensive beta-arenoreceptor with partial beta-2-agonist activity", PHARMACOLOGY, vol. 54, no. 4, April 1997 (1997-04-01), pages 211 - 224, XP009042020
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