Title:
PROBE FOR DISEASES WTH AMYLOID ACCUMULATION, AMYLOID-STAINING AGENT, REMEDY AND PREVENTIVE FOR DISEASES WITH AMYLOID ACCUMULATION AND DIAGNOSTIC PROBE AND STAINING AGENT FOR NEUROFIBRILLARY CHANGE
Document Type and Number:
WIPO Patent Application WO/2005/016888
Kind Code:
A1
Abstract:
It is intended to provide a compound highly specific to amyloid β-protein to be used in diagnosing diseases with amyloid β-protein accumulation, a staining agent specific to amyloid β-protein and treating and preventing diseases with amyloid β-protein accumulation. It is also intended to provide a probe for neurofibrillary changes and a staining agent for neurofibrillary changes.
Inventors:
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
Application Number:
PCT/JP2004/011546
Publication Date:
February 24, 2005
Filing Date:
August 11, 2004
Export Citation:
Assignee:
BF RES INST INC (JP)
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
International Classes:
A61K31/4184; A61K31/421; A61K31/422; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/47; A61K31/4709; A61K51/04; A61P25/28; C07D215/12; C07D235/06; C07D235/14; C07D263/32; C07D263/48; C07D263/56; C07D263/57; C07D277/42; C07D277/64; C07D403/04; C07D403/06; C07D413/04; C07D413/06; C07D417/04; C07D417/06; (IPC1-7): C07D215/12; A61K31/4184; A61K31/421; A61K31/422; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/47; A61K31/4709; A61K51/04; A61P25/28; C07D235/06; C07D263/32; C07D263/48; C07D263/57; C07D277/42; C07D277/64; C07D403/06; C07D413/04; C07D417/04; C07D417/06
Domestic Patent References:
| WO2003106439A1 | 2003-12-24 | |||
| WO2002016333A2 | 2002-02-28 | |||
| WO2003018070A1 | 2003-03-06 |
Foreign References:
| JP2004250407A | 2004-09-09 | |||
| JP2004067659A | 2004-03-04 | |||
| JP2003522174A | 2003-07-22 | |||
| JP2002518380A | 2002-06-25 | |||
| JPS58182640A | 1983-10-25 | |||
| JPH0228175A | 1990-01-30 |
Other References:
DATABASE CAPLUS [online] 25 March 2004 (2004-03-25), OKAMURA N. ET AL.: "Styrylbenzeoxazole derivatives for in vivo imaging of amyloid plaques in the brain", XP002982499, accession no. STN Database accession no. 2004:246241
KUNG H. ET AL.: "Nobel stilbenes as probes for amyloid plaques", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 50, 2001, pages 12740 - 12741, XP002982500
BOHRMANN B. ET AL.: "Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates", JOURNAL OF STRUCTURAL BIOLOGY, vol. 130, no. 2-3, 2000, pages 232 - 246, XP001083799
DATABASE CAPLUS 1 March 2000 (2000-03-01), KASSEM E.M.M.: "Synthesis of some new 2,4-disubstituted quinoline derivatives with expected biological activity", XP002982601
KUNG H. ET AL.: "Nobel stilbenes as probes for amyloid plaques", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 50, 2001, pages 12740 - 12741, XP002982500
BOHRMANN B. ET AL.: "Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates", JOURNAL OF STRUCTURAL BIOLOGY, vol. 130, no. 2-3, 2000, pages 232 - 246, XP001083799
DATABASE CAPLUS 1 March 2000 (2000-03-01), KASSEM E.M.M.: "Synthesis of some new 2,4-disubstituted quinoline derivatives with expected biological activity", XP002982601
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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