Title:
CONJUGATE OF ANTICANCER DRUG AND DIOSGENIN, PREPARATION METHOD THEREFOR, AND ANTICANCER COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/097403
Kind Code:
A1
Abstract:
The present invention relates to a conjugate of an anticancer drug and diosgenin (DG), a preparation method therefor, and an anticancer composition containing the same. According to the present invention, the conjugate in which an anticancer drug and diosgenin are bound by a linker is conjugated with a target anticancer drug by using DG, which is similar to a constituent ingredient of a cancer cell membrane, thereby having an effect of overcoming anticancer drug resistance and significantly improving anticancer activity by having enhanced penetrability into a cancer cell membrane.
Inventors:
CHUN CHANGJU (KR)
CAI BANGRONG (KR)
JING JIAO (KR)
CAI BANGRONG (KR)
JING JIAO (KR)
Application Number:
PCT/KR2017/001636
Publication Date:
May 31, 2018
Filing Date:
February 15, 2017
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
A61K47/50; A61K31/519; A61K31/704; A61K31/7068; A61K47/06; A61K47/22
Foreign References:
| US20050256069A1 | 2005-11-17 |
Other References:
JING, J.: "The Synthesis, Characterization and Anti-cancer Activity of the Doxorubicin Conjugate with Diosgenin as a Carrier", MASTER'S THESIS, February 2015 (2015-02-01), pages 1 - 34
ZHANG, D. ET AL.: "Transporter-targeted Cholic Acid-cytarabine Conjugates for Improved Oral Absorption", INTERNATIONAL JOURNAL OF PHARMACEUTICS, [ELECTRONIC PUBLISHING, vol. 511, no. 1, 1 July 2016 (2016-07-01), pages 161 - 169, XP029698786
LI, C. ET AL.: "A Self-assembled Nanoparticle Platform Based on Poly(ethylene glycol)-diosgenin Conjugates for Co-delivery of Anticancer Drugs", RSC ADVANCES, vol. 5, no. 91, 2015, pages 74828 - 74834, XP055487925
SANTOS, M. A. ET AL.: "Methotrexate y-hydroxamate Derivatives as Potential Dual Target Antitumor Drugs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 3, 2007, pages 1266 - 1274, XP005823067, DOI: doi:10.1016/j.bmc.2006.11.017
CAI, B. ET AL.: "Design, Synthesis of Methotrexate-diosgenin Conjugates and Biological Evaluation of Their Effect on Methotrexate Transport-resistant Cells", STEROIDS, vol. 116, 19 October 2016 (2016-10-19), pages 45 - 51, XP029822668
ZHANG, D. ET AL.: "Transporter-targeted Cholic Acid-cytarabine Conjugates for Improved Oral Absorption", INTERNATIONAL JOURNAL OF PHARMACEUTICS, [ELECTRONIC PUBLISHING, vol. 511, no. 1, 1 July 2016 (2016-07-01), pages 161 - 169, XP029698786
LI, C. ET AL.: "A Self-assembled Nanoparticle Platform Based on Poly(ethylene glycol)-diosgenin Conjugates for Co-delivery of Anticancer Drugs", RSC ADVANCES, vol. 5, no. 91, 2015, pages 74828 - 74834, XP055487925
SANTOS, M. A. ET AL.: "Methotrexate y-hydroxamate Derivatives as Potential Dual Target Antitumor Drugs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 3, 2007, pages 1266 - 1274, XP005823067, DOI: doi:10.1016/j.bmc.2006.11.017
CAI, B. ET AL.: "Design, Synthesis of Methotrexate-diosgenin Conjugates and Biological Evaluation of Their Effect on Methotrexate Transport-resistant Cells", STEROIDS, vol. 116, 19 October 2016 (2016-10-19), pages 45 - 51, XP029822668
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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