Title:
CONJUGATE COMPRISING ERYTHROPOIETIN AND A BRANCHED POLYMER STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2015/104008
Kind Code:
A8
Abstract:
The invention relates to: a conjugate comprising erythropoietin (EPO) and an asymmetric branched polymer structure having two monomethoxy-poly(ethylene glycol) (mPEG) branches, wherein the molecular mass of one of said mPEG branches is between 10 kDa and 14 kDa, and the molecular mass of the other mPEG branch is between 17 kDa and 23 kDa; and pharmaceutical compositions containing said conjugate. The invention also relates to a method for producing PEGylated EPO, characterised in that said protein is conjugated to an asymmetric branched polymer structure, having two mPEG branches with the above-mentioned molecular masses.
Inventors:
PÁEZ MEIRELES ROLANDO (CU)
AMARO GONZÁLEZ DANIEL ENRIQUE (CU)
CASTRO ODIO FIDEL RAÚL (CU)
HERNÁNDEZ VALDES YENISEL (CU)
RUIZ ESTRADA GLADYS AMALIA (CU)
AMARO GONZÁLEZ DANIEL ENRIQUE (CU)
CASTRO ODIO FIDEL RAÚL (CU)
HERNÁNDEZ VALDES YENISEL (CU)
RUIZ ESTRADA GLADYS AMALIA (CU)
Application Number:
PCT/CU2015/000001
Publication Date:
August 25, 2016
Filing Date:
January 08, 2015
Export Citation:
Assignee:
CT INGENIERIA GENETICA BIOTECNOLOGIA (CU)
CT INMUNOLOGIA MOLECULAR (CU)
CT INMUNOLOGIA MOLECULAR (CU)
International Classes:
A61K38/18; A61K47/48
Attorney, Agent or Firm:
GONZÁLEZ BLANCO, Sonia (Centro de Ingeniería Genética y BiotecnologíaAvenida 31 entre 158 y 19, Playa La Habana, CU)
Download PDF: