Title:
CONSTRUCTION METHOD FOR TUMOR IMMUNE CHECKPOINT INHIBITOR THERAPY EFFECTIVENESS EVALUATION MODEL BASED ON DNA METHYLATION SPECTRUM
Document Type and Number:
WIPO Patent Application WO/2022/141775
Kind Code:
A1
Abstract:
Provided are a DNA methylation feature site screening method and a construction method for a tumor immune checkpoint inhibitor therapy effectiveness evaluation model based on a DNA methylation spectrum.
Inventors:
GUO HAO (CN)
XU BINGXIANG (CN)
GE MINGHUI (CN)
YAN LINLIN (CN)
LI SHIMENG (CN)
REN YONG (CN)
XU BINGXIANG (CN)
GE MINGHUI (CN)
YAN LINLIN (CN)
LI SHIMENG (CN)
REN YONG (CN)
Application Number:
PCT/CN2021/076879
Publication Date:
July 07, 2022
Filing Date:
February 19, 2021
Export Citation:
Assignee:
JIANGSU SIMCERE MEDICAL DEVICE CO LTD (CN)
JIANGSU SIMCERE DIAGNOSTIC TECH CO LTD (CN)
JIANGSU SIMCERE DIAGNOSTIC TECH CO LTD (CN)
International Classes:
G16B20/00; C12Q1/6886; G16B40/00
Domestic Patent References:
| WO2019012105A1 | 2019-01-17 |
Foreign References:
| CN109355381A | 2019-02-19 | |||
| CN111630184A | 2020-09-04 | |||
| CN109715829A | 2019-05-03 | |||
| CN108135985A | 2018-06-08 | |||
| CN108064170A | 2018-05-22 |
Other References:
ANKUR CHAKRAVARTHY, ET. AL.: "Pan-cancer deconvolution of tumour composition using DNA methylation", NATURE COMMUNICATIONS, VOL. 9, 1 December 2018 (2018-12-01), pages 1 - 13, XP055703264, Retrieved from the Internet [retrieved on 20200610], DOI: 10.1038/s41467-018-05570-1
LIANG CONG, YU XIAOQING, LI BO, CHEN Y. ANN, CONEJO-GARCIA JOSE R., WANG XUEFENG: "DNA methylation-based immune cell deconvolution in solid tumors", BIORXIV, 26 April 2019 (2019-04-26), pages 1 - 21, XP055948093, Retrieved from the Internet [retrieved on 20220802], DOI: 10.1101/619965
ZHANG BAIHONG, YUE HONGYUN: "Predictors of response to tumor immunotherapy", AIZHENG JINZHAN = ONCOLOGY PROGRESS, ZHONGGUO XIEHE YIKE DAXUE CHUBANSHE, CN, vol. 17, no. 1, 1 January 2019 (2019-01-01), CN , pages 1 - 4,55, XP055948095, ISSN: 1672-1535, DOI: 10.11877/j.issn.1672-1535.2019.17.01.01
CRISTESCU RAZVAN, MOGG ROBIN, AYERS MARK, ALBRIGHT ANDREW, MURPHY ERIN, YEARLEY JENNIFER, SHER XINWEI, LIU XIAO QIAO, LU HONGCHAO,: "Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 362, no. 6411, 12 October 2018 (2018-10-12), US , pages 1 - 10, XP055948101, ISSN: 0036-8075, DOI: 10.1126/science.aar3593
LIANG CONG, YU XIAOQING, LI BO, CHEN Y. ANN, CONEJO-GARCIA JOSE R., WANG XUEFENG: "DNA methylation-based immune cell deconvolution in solid tumors", BIORXIV, 26 April 2019 (2019-04-26), pages 1 - 21, XP055948093, Retrieved from the Internet
ZHANG BAIHONG, YUE HONGYUN: "Predictors of response to tumor immunotherapy", AIZHENG JINZHAN = ONCOLOGY PROGRESS, ZHONGGUO XIEHE YIKE DAXUE CHUBANSHE, CN, vol. 17, no. 1, 1 January 2019 (2019-01-01), CN , pages 1 - 4,55, XP055948095, ISSN: 1672-1535, DOI: 10.11877/j.issn.1672-1535.2019.17.01.01
CRISTESCU RAZVAN, MOGG ROBIN, AYERS MARK, ALBRIGHT ANDREW, MURPHY ERIN, YEARLEY JENNIFER, SHER XINWEI, LIU XIAO QIAO, LU HONGCHAO,: "Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 362, no. 6411, 12 October 2018 (2018-10-12), US , pages 1 - 10, XP055948101, ISSN: 0036-8075, DOI: 10.1126/science.aar3593
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