Title:
CONTINUOUS PRODUCTION METHOD FOR 1,4-CYCLOHEXANEDIONE
Document Type and Number:
WIPO Patent Application WO/2022/134883
Kind Code:
A1
Abstract:
Disclosed is a continuous production method for 1,4-cyclohexanedione. The continuous production method comprises the steps of: step 1, adding dimethyl succinyl succinate (DMSS), water and a catalyst to a reaction kettle in proportion by metering, to obtain a mixed solution; step 2, carrying out a hydrolysis reaction on the mixed solution, obtained in step 1, at a preset temperature for a preset period of time, subsequently heating same to reflux, and opening a drain port at the bottom of the reaction kettle such that a hydrolysate flows out of the reaction kettle; step 3, extracting the hydrolysate obtained in step 2, to respectively obtain an organic layer and an aqueous layer; step 4, distilling the organic layer obtained in step 3, to obtain a crude product of 1,4-cyclohexanedione; and step 5, returning the aqueous layer obtained in step 3 to the reaction kettle, adding DMSS and water thereto, and repeating step 2 to step 5. By means of the continuous production process for 1,4-cyclohexanedione of the present invention, the problem in the prior art of a low production efficiency of producing 1,4-cyclohexanedione from DMSS as a raw material is solved.
Inventors:
WEI BING (CN)
GUO MINYI (CN)
LUO GUANGWEN (CN)
ZHANG ZHENGUO (CN)
XU LONGLONG (CN)
ZHAO SHAODAN (CN)
WANG WENYOU (CN)
KANG GAIQIAN (CN)
GUO MINYI (CN)
LUO GUANGWEN (CN)
ZHANG ZHENGUO (CN)
XU LONGLONG (CN)
ZHAO SHAODAN (CN)
WANG WENYOU (CN)
KANG GAIQIAN (CN)
Application Number:
PCT/CN2021/128687
Publication Date:
June 30, 2022
Filing Date:
November 04, 2021
Export Citation:
Assignee:
XIAN SUNWARD AEROMAT CO LTD (CN)
International Classes:
C07C45/67; C07C45/78; C07C45/80; C07C49/403
Foreign References:
| CN112679329A | 2021-04-20 | |||
| CN112679330A | 2021-04-20 | |||
| CN112645806A | 2021-04-13 | |||
| CN112013633A | 2020-12-01 | |||
| CN110818542A | 2020-02-21 |
Other References:
JIAO PING, ET AL.: "Synthesis of Enadoline", CHINESE JOURNAL OF PHARMACEUTICALS, SHANGHAI YIYAO GONGYE YANJIUYUAN,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CN, vol. 32, no. 8, 31 December 2001 (2001-12-31), CN , pages 342 - 345, XP055945276, ISSN: 1001-8255
NIELSEN, ARNOLD T.; CARPENTER, WAYNE R.: "1, 4-Cyclohexanedione", ORGANIC SYNTHESES, vol. 45, 31 December 1965 (1965-12-31), US , pages 25, XP009537759, ISSN: 0078-6209, DOI: 10.15227/orgsyn.045.0025
NIELSEN, ARNOLD T.; CARPENTER, WAYNE R.: "1, 4-Cyclohexanedione", ORGANIC SYNTHESES, vol. 45, 31 December 1965 (1965-12-31), US , pages 25, XP009537759, ISSN: 0078-6209, DOI: 10.15227/orgsyn.045.0025
Attorney, Agent or Firm:
SHENZHEN DISI-ELITE INTELLECTUAL PROPERTY AGENCY (CN)
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