PREPARATION METHOD FOR 1,4-CYCLOHEXANEDIONE

WIPO Patent Application WO/2022/134884

A1

Disclosed is a preparation method for 1,4-cyclohexanedione. The preparation method comprises the steps of: step 1, adding dimethyl succinylosuccinate (DMSS) to a reactor, adding water and starting to stir; step 2, adding a phase-shift catalyst to the reactor and starting to heat; step 3, raising the temperature to a reaction temperature, and then adding an acid and a transition metal salt to start a hydrolysis reaction; and step 4, conducting the hydrolysis reaction for a preset time to then obtain 1,4-cyclohexanedione. The preparation method for the 1,4-cyclohexanedione provided by the present invention solves the problems in the prior art of difficult DMSS hydrolysis and a long hydrolysis time when DMSS is used to prepare 1,4-cyclohexanedione.

JP2000502072

INDUSTRIAL APPLICABILITY Indane dimer (dimer) compound having smooth muscle relaxation and / or mast cell stabilizing and / or anti-inflammatory action.

XU LONGLONG (CN)
TAO JUNMIAO (CN)
ZHAO SHAODAN (CN)
WEI BING (CN)
ZHANG ZHENGUO (CN)
WANG WENYOU (CN)
KANG HUI (CN)
WANG GANG (CN)

PCT/CN2021/128703

June 30, 2022

November 04, 2021

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XIAN SUNWARD AEROMAT CO LTD (CN)

C07C45/67; C07C49/403

CN112679330A	2021-04-20
CN111187153A	2020-05-22
US4841096A	1989-06-20
CA1280756C	1991-02-26

PATWARDHAN S A, SUKH DEV: "Cyclohexane-1, 4-dione", SYNTHESIS, no. 8, 31 August 1971 (1971-08-31), pages 427 - 427, XP055946221, ISSN: 0090-6883
JIAO PING, QIU ZHUI BAI: "Synthesis of Enadoline", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 32, no. 8, 20 August 2001 (2001-08-20), pages 342 - 345, XP055945276, ISSN: 1001-8255

SHENZHEN DISI-ELITE INTELLECTUAL PROPERTY AGENCY (CN)

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