Title:
CONTROLLED RELEASE POLYMERIC GELS
Document Type and Number:
WIPO Patent Application WO2004081056
Kind Code:
A3
Abstract:
The present invention relates to an article comprising an elastomeric matrix and at least one biologically or nonbiologically active agent contained in the matrix, the said matrix being formed by reacting a carboxyl -terminated polymer, selected from either hydrophobic or hydrophilic carboxyl terminated polymers, with a polycarbodiimide, with (a) the said hydrophobic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polybutadi ene, carboxyl - terminated polyisoprene, carboxyl -terminated copolymers of butadiene with acrylonitrile, carboxyl -terminated copolymers of butadiene with styrene, carboxyl - terminated copolymers of isoprene with acrylonitrile, carboxyl -terminated copolymers of isoprene with styrene, and mixtures of the above, the carboxylic acid terminated polymer having an average molecular weight in the range of 1000 to 20000. (b) the said hydrophilic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polyethylene oxides, carboxyl-terminated polyether polyols which are copolymers of ethylene oxide and of an alkylene oxide having 3 -6 carbons atoms, in an amount of not more than 50 mole percent of said copolymer and ha ving molecular weight from 400 to 20000. (c) the said polycarbodiimide being selected from the group consisting of the aromatic, cycloaliphatic, aliphatic and heterocyclic carbodiimides, and mixtures of two of more of the above and the said polycarbodiimid e having an average functionality higher or equal to 2 and the carbodiimide/carboxylic acid molar ratio from polycarbodiimide and from carboxyl -terminated polymer being in the range of 0.7 to 6.
Inventors:
CHAO HERBERT (US)
TIAN NAN
TIAN NAN
Application Number:
PCT/IB2004/050244
Publication Date:
November 25, 2004
Filing Date:
March 12, 2004
Export Citation:
Assignee:
SARTOMER TECHNOLOGY CO INC (US)
CRAY VALLEY SA (FR)
CHAO HERBERT (US)
TIAN NAN
CRAY VALLEY SA (FR)
CHAO HERBERT (US)
TIAN NAN
International Classes:
A01N25/04; A01N65/00; A61K47/34; C08G18/69; C08G18/79; (IPC1-7): C08L75/04; A61K47/34
Domestic Patent References:
| WO1991019470A1 | 1991-12-26 |
Foreign References:
| US4594380A | 1986-06-10 | |||
| US4260718A | 1981-04-07 |
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