Title:
CORONAVIRUS VACCINE USING REPLICATION-DEFECTIVE ADENOVIRUS THAT SIMULTANEOUSLY EXPRESSES CORONAVIRUS SPIKE PROTEIN, NUCLEOCAPSID PROTEIN, AND PGSA PROTEIN
Document Type and Number:
WIPO Patent Application WO/2023/219198
Kind Code:
A1
Abstract:
The present invention relates to: a recombinant adenovirus in which coronavirus spike and nucleocapsid proteins and PgsA are expressed in the form inserted into the E1 region and the E3 region of a replication-defective adenovirus; and a coronavirus vaccine using same. A vaccine composition according to the present invention can induce immune responses to SARS-CoV-2 and a mutant virus thereof by inducing a humoral immune response and a cell-mediated response.
Inventors:
LEE DO YOUNG (KR)
OH YE NA (KR)
PARK YOUNG CHUL (KR)
OH YE NA (KR)
PARK YOUNG CHUL (KR)
Application Number:
PCT/KR2022/007208
Publication Date:
November 16, 2023
Filing Date:
May 20, 2022
Export Citation:
Assignee:
BL CORP (KR)
International Classes:
C12N7/00; A61K39/00; A61K39/215; A61P31/14; C12N15/86
Domestic Patent References:
| WO2019076882A1 | 2019-04-25 |
Foreign References:
| KR101471043B1 | 2014-12-09 | |||
| US20080267992A1 | 2008-10-30 |
Other References:
FENG LIQIANG, WANG QIAN, SHAN CHAO, YANG CHENCHEN, FENG YING, WU JIA, LIU XIAOLIN, ZHOU YIWU, JIANG RENDI, HU PEIYU, LIU XINGLONG,: "An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055920609, DOI: 10.1038/s41467-020-18077-5
RICE ADRIAN, VERMA MOHIT, SHIN ANNIE, ZAKIN LISE, SIELING PETER, TANAKA SHIHO, ADISETIYO HELTY, TAFT JUSTIN, PATEL ROSHEEL, BUTA S: "A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses", BIORXIV, 30 July 2020 (2020-07-30), pages 1 - 36, XP055929959, DOI: 10.1101/2020.07.29.227595
RICE ADRIAN, VERMA MOHIT, SHIN ANNIE, ZAKIN LISE, SIELING PETER, TANAKA SHIHO, ADISETIYO HELTY, TAFT JUSTIN, PATEL ROSHEEL, BUTA S: "A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses", BIORXIV, 30 July 2020 (2020-07-30), pages 1 - 36, XP055929959, DOI: 10.1101/2020.07.29.227595
Attorney, Agent or Firm:
SEWON PATENT LAW FIRM (KR)
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