Title:
CREPT MUTANT AND USE THEREOF IN INHIBITION OF TUMOR GROWTH
Document Type and Number:
WIPO Patent Application WO/2024/032486
Kind Code:
A1
Abstract:
The present invention relates to a CREPT mutant and use thereof in the inhibition of tumor growth. In particular, the present invention relates to a protein obtained by replacing a residue at position 134 of SEQ ID NO: 4 with a residue that cannot be phosphorylated, a nucleic acid encoding the protein, a vector and a cell comprising the nucleic acid, and use of the protein, the nucleic acid, or the vector in the preparation of a reagent for inhibiting the proliferation and/or migration of eukaryotic cells and an anti-cancer medicament. The present invention further relates to a method for treating cancers and a method for identifying whether a substance is a phosphorylation inhibitor for an S134 site of the CREPT protein or not.
Inventors:
CHANG ZHIJIE (CN)
REN FANGLI (CN)
WANG YINYIN (CN)
CHU JUN (CN)
REN FANGLI (CN)
WANG YINYIN (CN)
CHU JUN (CN)
Application Number:
PCT/CN2023/111173
Publication Date:
February 15, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07K14/47; A61K38/17; A61P35/00; C12N5/10; C12N15/12; C12N15/63; C12Q1/02; G01N33/68
Foreign References:
| CN116003566A | 2023-04-25 | |||
| CN116143907A | 2023-05-23 | |||
| CN108949718A | 2018-12-07 |
Other References:
LIU SULI, ZOU XIAO-HUI; FAN NING-LIN; SUN JI-CHAO; WU HUI-JUAN: "Construction and Efficiency Detection of CRISPR/Cas9 Gene Editing Vectors Targeting Serine at Position 134 of Mouse CREPT Gene", BIOTECHNOLOGY, vol. 32, no. 4, 16 August 2022 (2022-08-16), XP093139077, DOI: 10.16519/j.cnki.1004-311x.2022.04.0064
DING, LIDAN ET AL.: "CREPT/RPRD1B Associates with Aurora B to Regulate Cyclin B1 Expression for Accelerating the G2/M Transition in Gastric Cancer", CELL DEATH AND DISEASE, vol. 9, 5 December 2018 (2018-12-05), XP093137885, DOI: 10.1038/s41419-018-1211-8
DING, LIDAN ET AL.: "CREPT/RPRD1B Associates with Aurora B to Regulate Cyclin B1 Expression for Accelerating the G2/M Transition in Gastric Cancer", CELL DEATH AND DISEASE, vol. 9, 5 December 2018 (2018-12-05), XP093137885, DOI: 10.1038/s41419-018-1211-8
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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