Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CROSSLINKED POLYSACCHARIDE MICROPARTICLES AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2005/054301
Kind Code:
A1
Abstract:
It is intended to provide a long-lasting sustained release preparation of a drug such as a protein or a peptide which can hold the drug such as a protein or a peptide enclosed therein at a high enclosure ratio without inhibiting the biological activity of the drug, and is injectable, completely biodegradable and highly safe. A solution containing a polysaccharide (for example, hyaluronic acid) derivative having a crosslinkable functional group or its salt together with a drug, which has a low concentration so that the crosslinkage reaction can progress only at a low speed in the state of microparticles, is dehydrated to a concentration at which the crosslinkage can proceed. Thus, the crosslinkage reaction is induced during the concentration and the drug is enclosed in the crosslinked polysaccharide to give drug-carrying microparticles. Thus, an injectable sustained release preparation holding a drug such as a protein or a peptide highly efficiently enclosed therein while maintaining its biological activity and being capable of sustainedly releasing the drug over a long time can be obtained.

Inventors:
HAHN SEI KWANG (JP)
SHIMOBOJI TSUYOSHI (JP)
Application Number:
PCT/JP2004/016948
Publication Date:
June 16, 2005
Filing Date:
November 15, 2004
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
HAHN SEI KWANG (JP)
SHIMOBOJI TSUYOSHI (JP)
International Classes:
A61K9/16; A61K9/22; A61K47/36; C08B37/00; C08B37/08; C08J3/12; C08J3/24; A61K9/00; (IPC1-7): C08B37/08; A61K47/36; A61K9/22
Foreign References:
JP2001514316A2001-09-11
JPH11513047A1999-11-09
JP2000510100A2000-08-08
JPH11509256A1999-08-17
JPH0959303A1997-03-04
JPH10509696A1998-09-22
JP2000248002A2000-09-12
JPH11319066A1999-11-24
JPH11193246A1999-07-21
Other References:
None
See also references of EP 1683812A4
Attorney, Agent or Firm:
Shamoto, Ichio (Section 206 New Ohtemachi Bldg.,, 2-1, Ohtemachi 2-chome, Chiyoda-ku Toky, JP, JP)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: POLYSACCHARIDE DERIVATIVES, THEIR PRODUCTION AND USE

Next Patent: DRUG CARRIER AND PROCESS FOR PRODUCING THE SAME