Title:
CRYSTAL FORM OF FGFR4 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/207944
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of an FGFR4 inhibitor and use thereof. The present invention provides a compound of formula B in crystalline form. The compound of formula B of the present invention has excellent FGFR4 kinase inhibitory activity and Huh-7 tumor cell proliferation inhibition. The pharmacokinetic effect in the present compound is better than that in the enantiomers or racemates thereof. The crystalline form of the present compound and especially the optional crystal forms thereof have good solubility, mass stability, and thermodynamic stability, and can be easily made into a medicament.
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Inventors:
PENG XIAOSHI (CN)
ZHANG HANCHENG (CN)
YANG MIN (CN)
YE XIANGYANG (CN)
ZHANG DANDAN (CN)
LIANG XINLEI (CN)
YAN CUIQIN (CN)
LI YUQIN (CN)
YAO LEI (CN)
ZHANG HANCHENG (CN)
YANG MIN (CN)
YE XIANGYANG (CN)
ZHANG DANDAN (CN)
LIANG XINLEI (CN)
YAN CUIQIN (CN)
LI YUQIN (CN)
YAO LEI (CN)
Application Number:
PCT/CN2023/090492
Publication Date:
November 02, 2023
Filing Date:
April 25, 2023
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)
HANGZHOU INNOGATE PHARMA CO LTD (CN)
CSPC OUYI PHARMACEUTICAL CO LTD (CN)
HANGZHOU INNOGATE PHARMA CO LTD (CN)
CSPC OUYI PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4985; C07D519/00; A61P35/00
Domestic Patent References:
| WO2017198149A1 | 2017-11-23 |
Foreign References:
| CN108948004A | 2018-12-07 | |||
| CN109071532A | 2018-12-21 | |||
| CN109745321A | 2019-05-14 | |||
| CN113072550A | 2021-07-06 |
Other References:
SUN CHANG'AN, FANG LEI, ZHANG XIAOBING, GAO PENG, GOU SHAOHUA: "Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 10, 1 May 2019 (2019-05-01), AMSTERDAM, NL, pages 1932 - 1941, XP093105260, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.04.018
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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