CRYSTAL OF HYDROXYNOREPHEDRIN DERIVATIVE HYDROCHLORIDE 1/4 HYDRATE

Title:

CRYSTAL OF HYDROXYNOREPHEDRIN DERIVATIVE HYDROCHLORIDE 1/4 HYDRATE

Document Type and Number:

WIPO Patent Application WO/2006/118087

Kind Code:

A1

Abstract:

There is provided ethyl (-)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride 1/4 hydrate or its crystal, which can be identified by characteristic diffraction peaks of powder X-ray diffractometry, differential scanning calorimetry, etc., obtained by producing, through specified process, ethyl 2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate.

Inventors:

ISAWA HIDETOSHI (JP)
TODA MICHIO (JP)

Application Number:

PCT/JP2006/308591

Publication Date:

November 09, 2006

Filing Date:

April 24, 2006

Export Citation:

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Assignee:

KISSEI PHARMACEUTICAL (JP)
ISAWA HIDETOSHI (JP)
TODA MICHIO (JP)

International Classes:

C07C217/54; A61K31/215; A61P13/02

Domestic Patent References:

WO2003024916A1

2003-03-27

Other References: