Title:
CRYSTAL STRUCTURE OF CD147 EXTRACELLULAR REGION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/023995
Kind Code:
A1
Abstract:
Provided are the crystal of CD147 extracellular region, the preparation method
of the crystal and three-dimensional structure of the CD147 extracellular region.
The three-dimensional structure can be used for determination of the active
sites of CD147 extracellular region by computer modeling and molecular docking.
The crystal and/or three-dimensional structure can be used for structure-based
drug design and selection of antibodies, ligands and other interacting molecules
of the CD147 extracellular region.
Inventors:
CHEN ZHINAN (CN)
ZHU PING (CN)
YU XIAOLING (CN)
YANG BIN (CN)
YANG XIANGMIN (CN)
ZHANG ZHENG (CN)
ZHU PING (CN)
YU XIAOLING (CN)
YANG BIN (CN)
YANG XIANGMIN (CN)
ZHANG ZHENG (CN)
Application Number:
PCT/CN2007/003034
Publication Date:
February 26, 2009
Filing Date:
October 24, 2007
Export Citation:
Assignee:
CHEN ZHINAN (CN)
ZHU PING (CN)
YU XIAOLING (CN)
YANG BIN (CN)
YANG XIANGMIN (CN)
ZHANG ZHENG (CN)
ZHU PING (CN)
YU XIAOLING (CN)
YANG BIN (CN)
YANG XIANGMIN (CN)
ZHANG ZHENG (CN)
International Classes:
C07K14/705; C07K19/00; C30B7/02; C30B29/58; C40B30/04; G01N33/50; G06F17/30; G06F17/50; G06F19/00; G16B15/30
Foreign References:
| CN1381461A | 2002-11-27 | |||
| CN1749268A | 2006-03-22 |
Other References:
BAO GQ ET AL: "Preparation of Human Fab Antibodies Against HAb18G by Guided Selection and Chain Shuffling Technique", CHIN. J. CELL. MOL. IMMUNOL., vol. 20, no. 4, August 2004 (2004-08-01), pages 437 - 440, XP009135202
XING JL ET AL: "Prokaryotic Expression and Immunological Analysis of the Extracellular Domain of Hepatoma Associated Antigen HAb18G", J. FOURTH MIL. MED. UNIV., vol. 24, no. 12, December 2003 (2003-12-01), pages 1057 - 1060, XP009135064
CHOTHIA C; JONES EY: "The molecular structure of cell adhesion molecules", ANNU REV BIOCHEM., vol. 66, 1997, pages 823 - 62, XP055030383, DOI: doi:10.1146/annurev.biochem.66.1.823
VAUGHN DE; BJORKMAN PJ: "The (Greek) key to structures of neural adhesion molecules", NEURON, vol. 16, no. 2, 1996, pages 261 - 73
JONES ET AL., CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1997, pages 652 - 656
See also references of EP 2194065A4
XING JL ET AL: "Prokaryotic Expression and Immunological Analysis of the Extracellular Domain of Hepatoma Associated Antigen HAb18G", J. FOURTH MIL. MED. UNIV., vol. 24, no. 12, December 2003 (2003-12-01), pages 1057 - 1060, XP009135064
CHOTHIA C; JONES EY: "The molecular structure of cell adhesion molecules", ANNU REV BIOCHEM., vol. 66, 1997, pages 823 - 62, XP055030383, DOI: doi:10.1146/annurev.biochem.66.1.823
VAUGHN DE; BJORKMAN PJ: "The (Greek) key to structures of neural adhesion molecules", NEURON, vol. 16, no. 2, 1996, pages 261 - 73
JONES ET AL., CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1997, pages 652 - 656
See also references of EP 2194065A4
Attorney, Agent or Firm:
NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE (Block A Investment Plaza, 27 Jinrongdajie, Beijing 2, CN)
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