Title:
CRYSTALLINE FORM I OF MELANOCORTIN RECEPTOR AGONIST COMPOUND AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2022/139443
Kind Code:
A1
Abstract:
The present invention relates to crystalline form I of a compound represented by chemical formula 1, a method for preparing same, and a pharmaceutical composition comprising same. Crystalline form I of the compound represented by chemical formula 1 of the present invention may be characterized by the XRPD pattern, the DSC profile, the TGA profile, and/or the DVS profile.
Inventors:
KIM JI YOON (KR)
LEE SANG DAE (KR)
KIM RI RA (KR)
KIM SUNG WON (KR)
LEE HO YEON (KR)
CHUN SEUL AH (KR)
HAM JIN OK (KR)
LEE SANG DAE (KR)
KIM RI RA (KR)
KIM SUNG WON (KR)
LEE HO YEON (KR)
CHUN SEUL AH (KR)
HAM JIN OK (KR)
Application Number:
PCT/KR2021/019583
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
C07D403/06; A61K31/5377; A61P3/04; A61P3/10; A61P15/10; A61P29/00
Domestic Patent References:
WO2021091283A1 | 2021-05-14 | |||
WO2008007930A1 | 2008-01-17 | |||
WO2010056022A2 | 2010-05-20 | |||
WO2004092126A2 | 2004-10-28 |
Foreign References:
KR20100053458A | 2010-05-20 | |||
KR20140108222A | 2014-09-05 | |||
KR20190141649A | 2019-12-24 |
Other References:
WANLONG JIANG,JOE A.TRAN,FABIO C.TUCCI,BETH A.FLECK,SAM R.HOARE,STACY MARKISON,JENNY WEN,CAROLINE W.CHEN,DRAGAN MARINKOVIC,MELISSA: "Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 17, no. 23, 22 October 2007 (2007-10-22), Amsterdam NL , pages 6546 - 6552, XP022325933, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.09.079
CHEN, C. JIANG, W. TRAN, J.A. TUCCI, F.C. FLECK, B.A. MARKISON, S. WEN, J. MADAN, A. HOARE, S.R. FOSTER, A.C. : "Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 1, 4 November 2007 (2007-11-04), Amsterdam NL , pages 129 - 136, XP022410870, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.115
TRAN, J.A. ; TUCCI, F.C. ; ARELLANO, M. ; JIANG, W. ; CHEN, C.W. ; MARINKOVIC, D. ; FLECK, B.A. ; WEN, J. ; FOSTER, A.C. ; CHEN, C: "Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 6, 15 March 2008 (2008-03-15), Amsterdam NL , pages 1931 - 1938, XP025694996, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2008.01.125
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DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J., vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., GENES DEV., vol. 11, 1997, pages 593 - 602
OILMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, no. 1 Pt 2, 1998, pages R248 - 54
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MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
CHEN, C. JIANG, W. TRAN, J.A. TUCCI, F.C. FLECK, B.A. MARKISON, S. WEN, J. MADAN, A. HOARE, S.R. FOSTER, A.C. : "Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 1, 4 November 2007 (2007-11-04), Amsterdam NL , pages 129 - 136, XP022410870, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.115
TRAN, J.A. ; TUCCI, F.C. ; ARELLANO, M. ; JIANG, W. ; CHEN, C.W. ; MARINKOVIC, D. ; FLECK, B.A. ; WEN, J. ; FOSTER, A.C. ; CHEN, C: "Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 6, 15 March 2008 (2008-03-15), Amsterdam NL , pages 1931 - 1938, XP025694996, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2008.01.125
SCHWARTZ ET AL., NATURE, vol. 404, 2000, pages 661 - 671
WIKBERG ET AL., PHARM RES, vol. 42, no. 5, 2000, pages 393 - 420
WIKBERG, EUR. J. PHARMACOL, vol. 375, 1999, pages 295 - 310
DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J., vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., GENES DEV., vol. 11, 1997, pages 593 - 602
OILMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, no. 1 Pt 2, 1998, pages R248 - 54
LEE M. D. ET AL., FASEB J, vol. 12, 1998, pages A552
MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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