Title:
CRYSTAL TYPE II OF MELANOCORTIN RECEPTOR AGONIST COMPOUND AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2022/139444
Kind Code:
A1
Abstract:
The present invention relates to a crystal type II of a compound represented by chemical formula 1, a method for preparing same, and a pharmaceutical composition comprising same. The crystal type II of the compound represented by chemical formula 1 of the present invention can be characterized by an XRPD pattern, a DSC profile, a TGA profile, and/or a DVS profile.
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Inventors:
KIM JI YOON (KR)
LEE HO YEON (KR)
HAM JIN OK (KR)
CHUN SEUL AH (KR)
KIM SUNG WON (KR)
LEE HO YEON (KR)
HAM JIN OK (KR)
CHUN SEUL AH (KR)
KIM SUNG WON (KR)
Application Number:
PCT/KR2021/019584
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
C07D403/06; A61K31/5377; A61P3/04; A61P3/10; A61P15/10; A61P29/00
Domestic Patent References:
WO2021091283A1 | 2021-05-14 | |||
WO2008007930A1 | 2008-01-17 | |||
WO2010056022A2 | 2010-05-20 | |||
WO2004092126A2 | 2004-10-28 |
Foreign References:
KR20100053458A | 2010-05-20 | |||
KR20140108222A | 2014-09-05 | |||
KR20200180808A | ||||
KR20190141649A | 2019-12-24 |
Other References:
WANLONG JIANG,JOE A.TRAN,FABIO C.TUCCI,BETH A.FLECK,SAM R.HOARE,STACY MARKISON,JENNY WEN,CAROLINE W.CHEN,DRAGAN MARINKOVIC,MELISSA: "Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 23, 22 October 2007 (2007-10-22), Amsterdam NL, pages 6546 - 6552, XP022325933, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.09.079
CHEN, C. JIANG, W. TRAN, J.A. TUCCI, F.C. FLECK, B.A. MARKISON, S. WEN, J. MADAN, A. HOARE, S.R. FOSTER, A.C. : "Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 4 November 2007 (2007-11-04), Amsterdam NL , pages 129 - 136, XP022410870, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.115
TRAN; TUCCI J A; ARELLANO F C; JIANG M; CHEN W; MARINKOVIC C W; FLECK D; WEN B A; FOSTER J; CHEN A C; C: "Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 6, 7 February 2008 (2008-02-07), Amsterdam NL , pages 1931 - 1938, XP022526309, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.11.128
SCHWARTZ ET AL., NATURE, vol. 404, 2000, pages 661 - 671
WIKBERG ET AL., PHARM RES, vol. 42, no. 5, 2000, pages 393 - 420
WIKBERG, EUR. J. PHARMACOL, vol. 375, 1999, pages 295 - 310
DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J., vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., GENES DEV., vol. 11, 1997, pages 593 - 602
OILMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, no. 1 Pt 2, 1998, pages R248 - 54
LEE M. D. ET AL., FASEB J, vol. 12, 1998, pages A552
MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
CHEN, C. JIANG, W. TRAN, J.A. TUCCI, F.C. FLECK, B.A. MARKISON, S. WEN, J. MADAN, A. HOARE, S.R. FOSTER, A.C. : "Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 4 November 2007 (2007-11-04), Amsterdam NL , pages 129 - 136, XP022410870, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.115
TRAN; TUCCI J A; ARELLANO F C; JIANG M; CHEN W; MARINKOVIC C W; FLECK D; WEN B A; FOSTER J; CHEN A C; C: "Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 6, 7 February 2008 (2008-02-07), Amsterdam NL , pages 1931 - 1938, XP022526309, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.11.128
SCHWARTZ ET AL., NATURE, vol. 404, 2000, pages 661 - 671
WIKBERG ET AL., PHARM RES, vol. 42, no. 5, 2000, pages 393 - 420
WIKBERG, EUR. J. PHARMACOL, vol. 375, 1999, pages 295 - 310
DOUGLAS ET AL., EUR J PHARM, vol. 450, 2002, pages 93 - 109
O'RAHILLY ET AL., NATURE MED, vol. 10, 2004, pages 351 - 352
YEN, TT ET AL., FASEB J., vol. 8, 1994, pages 479 - 488
LU D. ET AL., NATURE, vol. 371, 1994, pages 799 - 802
SHUTTER ET AL., GENES DEV., vol. 11, 1997, pages 593 - 602
OILMAN ET AL., SCIENCE, vol. 278, 1997, pages 135 - 138
KASK ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 245, 1998, pages 90 - 93
THIELE T. E. ET AL., AM J PHYSIOL, vol. 274, no. 1 Pt 2, 1998, pages R248 - 54
LEE M. D. ET AL., FASEB J, vol. 12, 1998, pages A552
MURPHY B. ET AL., J APPL PHYSIOL, vol. 89, 2000, pages 273 - 82
MARSH ET AL., NAT GENET, vol. 21, 1999, pages 119 - 122
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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