Title:
CRYSTALLINE FORMS
Document Type and Number:
WIPO Patent Application WO/2023/008585
Kind Code:
A1
Abstract:
The present invention relates to novel crystalline forms of (R)-N-((S)-1-(4-(3,3-dimethyl-2-oxoindolin-1-yl)piperidin-1-yl)-1-oxo-4-phenylbutan-2-yl)piperidine-3-carboxamide hydrochloride (HCl-salt), and to pharmaceutical compositions thereof, process for preparation or isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of various diseases or disorders which are mediated by motilin receptor activity.
Inventors:
AOYAMA HIDEYUKI (JP)
NUMATA TOYOHARU (JP)
SUDO MASAKI (JP)
IWATA YASUHIRO (JP)
NUMATA TOYOHARU (JP)
SUDO MASAKI (JP)
IWATA YASUHIRO (JP)
Application Number:
PCT/JP2022/029430
Publication Date:
February 02, 2023
Filing Date:
August 01, 2022
Export Citation:
Assignee:
RAQUALIA PHARMA INC (JP)
International Classes:
C07D401/14; A61K31/4545; A61P1/00; A61P1/04; A61P1/08; A61P1/10; A61P7/00; A61P7/12; A61P35/00; A61P43/00
Domestic Patent References:
| WO2010098145A1 | 2010-09-02 |
Other References:
STEPHEN M BERGE , LYLE D BIGHLEY , DONALD C MONKHOUSE: "Pharmaceutical salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1 January 1977 (1977-01-01), US , pages 1 - 19, XP002675560, ISSN: 0022-3549, DOI: 10.1002/jps.2600660104
STEPHEN BYRN, RALPH PFEIFFER, MICHAEL GANEY, CHARLES HOIBERG , GUIRAG POOCHIKIAN: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1 July 1995 (1995-07-01), pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
STEPHEN BYRN, RALPH PFEIFFER, MICHAEL GANEY, CHARLES HOIBERG , GUIRAG POOCHIKIAN: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1 July 1995 (1995-07-01), pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
Attorney, Agent or Firm:
IWATANI Ryo (JP)
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