Title:
CRYSTALLINE MODIFICATION OF HYDROCHLORIDE OF 2-DIMETHYLAMINOETHYL ETHER OF n-BUTYLAMINO BENZOIC ACID, METHOD OF OBTAINING IT AND PHARMACEUTICAL PREPARATION FOR ANESTHESIA OF THE EYE BASED THEREUPON
Document Type and Number:
WIPO Patent Application WO/1993/004034
Kind Code:
A1
Abstract:
A new crystalline modification of hydrochloride of 2-dimethylaminoethyl ether of n-butylamino benzoic acid is characterized by one endothermic melting effect at a temperature of 148.6° U 0.3 °C and by the values of the interplane distances d and of relative intensities of reflexes (I). A method of obtaining said substance consists in that the solution of hydrochloride of 2-dimethylaminoethyl ether of n-butylamino benzoic acid of polymorphic form in the water or in an organic solvent or in their mixture is cooled by means of a cooling agent at a speed no less than 8 °C/min up to its full crystallization with subsequent drying of the thus obtained crystals. The claimed substance has local anesthesia properties and is an active agent of a pharmaceutical preparation for anesthesia of the eye (the content of the active substance from 0.05 to 0.5 percent by weight).
More Like This:
Inventors:
LEONIDOV NIKOLAI BORISOVICH (SU)
Application Number:
PCT/SU1991/000168
Publication Date:
March 04, 1993
Filing Date:
August 19, 1991
Export Citation:
Assignee:
VREMENNY MEZHOTRASLEVOI NT KOL (SU)
International Classes:
C07C227/42; C07C229/60; (IPC1-7): A61K9/08; A61K31/245; A61K31/72; C07C227/38; C07C227/42; C07C229/60
Other References:
M.D. MASHKOVSKY; Lekarstvennye sredstva, vol. I, 1986, Meditsina (Moscow), pages 325-328, 332-333.
MEZHDUNARODNAYA FARMAKOPEYA, vol. 3 "Spetsifikatsiya dlya kontrolya kachestva farmatsevticheskikh preparatov", 1990, voz (Geneva), pages 356-358.
M.V. RUBTSOV et al. "Sinteticheskie khimikofarmatsevticheskie preparaty", 1971 Meditsina (Moscow), pages 74-77.
Thermochimica Acta vol. 153, 1989, Elsevier Science Publishers B.V. (Amsterdam), pages 11-26, R. CURINI et al. "Thermal analytical techniques applied to the narcotic field: cocaine analysis".
See also references of EP 0553351A4
MEZHDUNARODNAYA FARMAKOPEYA, vol. 3 "Spetsifikatsiya dlya kontrolya kachestva farmatsevticheskikh preparatov", 1990, voz (Geneva), pages 356-358.
M.V. RUBTSOV et al. "Sinteticheskie khimikofarmatsevticheskie preparaty", 1971 Meditsina (Moscow), pages 74-77.
Thermochimica Acta vol. 153, 1989, Elsevier Science Publishers B.V. (Amsterdam), pages 11-26, R. CURINI et al. "Thermal analytical techniques applied to the narcotic field: cocaine analysis".
See also references of EP 0553351A4
Download PDF: