Title:
CRYSTALS OF 2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID, METHOD FOR PRODUCING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/171254
Kind Code:
A1
Abstract:
C crystals of febuxostat are produced by heating a mixture of C crystals and an amorphous form of febuxostat. The content the amorphous form of febuxostat is lowered by heating a formulation or sample including an amorphous form of febuxostat. A stable formulation or sample including C crystals of febuxostat is produced. Novel crystals of febuxostat are provided by heating an amorphous form of febuxostat. Measurement is conducted by differential scanning calorimetry, and the novel crystals and amorphous form of febuxostat are detected and quantified by measuring the endothermic peak level that appears at approximately 211°C.
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Inventors:
KOMATSU HIROSHI (JP)
TENDO ATSUSHI (JP)
YOSHIDA SHINICHI (JP)
NOMURA YUTAKA (JP)
YANAGIMOTO GO (JP)
YUMOTO AIKO (JP)
MOCHIZUKI NOBUTAKA (JP)
HATAKEDA YASUSHI (JP)
KUMAGAI HIDEHARU (JP)
TENDO ATSUSHI (JP)
YOSHIDA SHINICHI (JP)
NOMURA YUTAKA (JP)
YANAGIMOTO GO (JP)
YUMOTO AIKO (JP)
MOCHIZUKI NOBUTAKA (JP)
HATAKEDA YASUSHI (JP)
KUMAGAI HIDEHARU (JP)
Application Number:
PCT/JP2016/062767
Publication Date:
October 27, 2016
Filing Date:
April 22, 2016
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
C07D277/56; A61K9/20; A61K31/426; A61P19/06
Domestic Patent References:
| WO2003082279A1 | 2003-10-09 | |||
| WO1999065885A1 | 1999-12-23 | |||
| WO2006101082A1 | 2006-09-28 | |||
| WO2015063561A1 | 2015-05-07 |
Foreign References:
| JP2012529537A | 2012-11-22 | |||
| JP2005511780A | 2005-04-28 | |||
| JPH1053576A | 1998-02-24 | |||
| CN101684107A | 2010-03-31 | |||
| CN101412700A | 2009-04-22 |
Other References:
YUICHI TOZUKA ET AL.: "Evaluation of Molecular State of Medicines by Differential Scanning Calorimetry", NETSU SOKUTEI, vol. 31, no. 2, 2004, pages 69 - 73, XP055323415, ISSN: 1884-1899
Attorney, Agent or Firm:
HASHIMOTO Satoshi et al. (JP)
Satoshi Hashimoto (JP)
Satoshi Hashimoto (JP)
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