Title:
CRYSTALS OF VITAMIN D DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/1998/000397
Kind Code:
A1
Abstract:
A crystal of the compound of the structural formula (I); crystals of vitamin D derivatives prepared by purifying unpurified or roughly purified vitamin D derivatives by reversed phase chromatography and crystallizing the purified derivatives in organic solvents; novel by-products formed in the synthesis of vitamin D derivatives; and a process for the purification of vitamin D derivatives or intermediates thereof, which enables the constant and mass supply of high-purity vitamin D derivatives, particularly ED-71.
Inventors:
YAMAUCHI TSUYOSHI (JP)
Application Number:
PCT/JP1997/002060
Publication Date:
January 08, 1998
Filing Date:
June 16, 1997
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
YAMAUCHI TSUYOSHI (JP)
YAMAUCHI TSUYOSHI (JP)
International Classes:
C07C401/00; C07J9/00; C07J71/00; (IPC1-7): C07C401/00; C07J9/00
Foreign References:
| JPS5115609A | 1976-02-07 | |||
| JPH07112998A | 1995-05-02 | |||
| JPH07173133A | 1995-07-11 |
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, Vol. 4, No. 12, p. 1523-1526.
Attorney, Agent or Firm:
Yuasa, Kyozo (Section 206 New Ohtemachi Building, 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
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