Title:
CULTURE SUBSTRATE AND CULTURE METHOD FOR CARTILAGE TISSUE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2007/066650
Kind Code:
A1
Abstract:
It is intended to provide a substrate for culturing a cartilage cell and a culture method to be used for cartilage tissue regeneration. The object can be achieved by a culture substrate which is a culture substrate for cartilage tissue regeneration containing a fabric or a knit comprising a chitosan/acidic biological polymer hybrid fiber in which the inside of the fiber comprises chitosan or a salt thereof and the surface of the fiber is covered with a composite of chitosan and an acidic biological polymer selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate, and in which the space between threads of the fabric or the knit is 250 to 500 μm and the porosity of the inside of the substrate is 65 to 94%.
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Inventors:
MAJIMA TOKIFUMI (JP)
IWASAKI NORIMASA (JP)
HARADA KAZUO (JP)
NONAKA SACHIKO (JP)
KASAHARA YASUHIKO (JP)
IWASAKI NORIMASA (JP)
HARADA KAZUO (JP)
NONAKA SACHIKO (JP)
KASAHARA YASUHIKO (JP)
Application Number:
PCT/JP2006/324241
Publication Date:
June 14, 2007
Filing Date:
December 05, 2006
Export Citation:
Assignee:
CHEMICAL BIOLOGY INST (JP)
MAJIMA TOKIFUMI (JP)
IWASAKI NORIMASA (JP)
HARADA KAZUO (JP)
NONAKA SACHIKO (JP)
KASAHARA YASUHIKO (JP)
MAJIMA TOKIFUMI (JP)
IWASAKI NORIMASA (JP)
HARADA KAZUO (JP)
NONAKA SACHIKO (JP)
KASAHARA YASUHIKO (JP)
International Classes:
A61L27/00; C12N5/077
Foreign References:
| JP2004216119A | 2004-08-05 | |||
| JP2005237956A | 2005-09-08 | |||
| JP2005131365A | 2005-05-26 |
Other References:
YAMANE S.: "Chitosan.Hyaluronic Acid Hybrid Sen'i o Mochiita Sanjigen Nankotsu Saibo Baiyo", HOKKAIDO SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY ZASSHI, vol. 47, no. 1, 29 August 2005 (2005-08-29), pages 54, XP003014201
YAMANE S. ET AL.: "Chitosan.Hyaluronic Acid Hybrid Sen'i o Mochiita Sanjigen Scaffold no Nankotsu Saibo Baiyo ni Okeru Hyoka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 78, no. 8, 2004, pages S851, XP003014202
YAMANE S. ET AL.: "Nankotsu Soshiki Saisei ni Mukete no Arata na Sanjigen Scaffold no Kaihatsu", JAPANESE JOURNAL OF TRANSPLANTATION, vol. 37, 2002, pages 214, XP003014203
YAMANE S. ET AL.: "Chitosan.Hyaluronic Acid Hybrid Sen'i o Mochiita Sanjigen Scaffold no Nankotsu Saibo Baiyo ni Okeru Hyoka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 78, no. 8, 2004, pages S851, XP003014202
YAMANE S. ET AL.: "Nankotsu Soshiki Saisei ni Mukete no Arata na Sanjigen Scaffold no Kaihatsu", JAPANESE JOURNAL OF TRANSPLANTATION, vol. 37, 2002, pages 214, XP003014203
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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