Title:
CYCLIC AMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/072402
Kind Code:
A1
Abstract:
The present invention pertains to a compound having an exceptional effect for inhibiting retinoic-acid-receptor-related orphan receptors γt, or a pharmacologically acceptable salt thereof. A compound represented by general formula (I) (in the formula, R1 represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group; R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like; R3 represents a hydrogen atom, a C2-C7 carboxyalkyl group, or a hydroxyl group; R4 represents a halogen atom or a C1-C6 alkyl group; R5 represents a hydrogen atom or a C1-C6 alkyl group; R6 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group; Q1 represents a nitrogen atom or a group represented by the formula =CH-; Q2 represents a nitrogen atom or a group represented by the formula =CH-; a group represented by the formula -U-T- represents a group represented by the formula -CH2-CH2-, or the like; Y represents a methylene group or an oxygen atom; V represents a nitrogen atom or a group represented by the formula =C(R7)-; R7 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like; E represents a piperidine-1-yl group, piperidine-4-yl group, or 1,2,3,6-tetrahydropyridine-4-yl group optionally substituted independently by from one to four groups selected from substituent group A, or the like; substituent group A includes C1-C6 alkyl groups, C1-C6 alkyl halide groups, groups represented by the formula -L-R8, and the like; L represents a carbonyl group, an oxalyl group, or the like; R8 represents a C1-C6 alkyl group, a C1-C6 hydroxyalkyl group, a mono-C1-C6 alkylamino group, or the like), or a pharmacologically acceptable salt thereof.
Inventors:
NAGAMOCHI MASATOSHI (JP)
GOTANDA KENTOKU (JP)
NOGUCHI TETSUJI (JP)
GOTO TAIJI (JP)
SASAKI JUNKO (JP)
TORIHATA MUNEFUMI (JP)
YOSHINO TOSHIHARU (JP)
ISOBE TAKASHI (JP)
RAMADASS VENKATARAMANAN (JP)
GOTANDA KENTOKU (JP)
NOGUCHI TETSUJI (JP)
GOTO TAIJI (JP)
SASAKI JUNKO (JP)
TORIHATA MUNEFUMI (JP)
YOSHINO TOSHIHARU (JP)
ISOBE TAKASHI (JP)
RAMADASS VENKATARAMANAN (JP)
Application Number:
PCT/JP2015/080982
Publication Date:
May 12, 2016
Filing Date:
November 04, 2015
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07D209/32; A61K31/404; A61K31/438; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61P1/00; A61P1/04; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D491/113
Domestic Patent References:
| WO2013171729A2 | 2013-11-21 | |||
| WO2013029338A1 | 2013-03-07 | |||
| WO2014086894A1 | 2014-06-12 |
Foreign References:
| JPS4844272A | 1973-06-26 |
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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