CYCLIC COMPOUND - TAKEDA PHARMACEUTICALS CO

Title:

CYCLIC COMPOUND

Document Type and Number:

WIPO Patent Application WO/2016/181894

Kind Code:

A1

Abstract:

The present invention provides a compound which has an excellent TLR4 signaling inhibitory effect and is useful as a prophylactic or therapeutic agent for diseases such as autoimmune diseases and/or inflammatory diseases, chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), hepatic disorders, or ischemia-reperfusion injuries (IRI). The present invention relates to a compound represented by formula (I) [in the formula, each symbol is as disclosed in the description] or a salt thereof.

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Inventors:

KOBAYASHI TOSHITAKE (JP)
SAITOH MORIHISA (JP)
WADA YASUFUMI (JP)
NARA HIROSHI (JP)
NEGORO NOBUYUKI (JP)
YAMASAKI MASASHI (JP)
TANAKA TAKAHIRO (JP)
KITAMOTO NAOMI (JP)

Application Number:

PCT/JP2016/063628

Publication Date:

November 17, 2016

Filing Date:

May 06, 2016

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Assignee:

TAKEDA PHARMACEUTICALS CO (JP)

International Classes:

C07D317/72; A61K31/357; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/06; A61P3/10; A61P7/06; A61P9/02; A61P9/10; A61P13/12; A61P17/02; A61P25/16; A61P25/28; A61P25/32; A61P29/00; A61P31/04; A61P31/06; A61P31/10; A61P31/12; A61P31/18; A61P31/22; A61P35/00; A61P35/02; A61P37/08

Foreign References:

JP2008260760A	2008-10-30
JP2004002370A	2004-01-08

Other References:

LI, YAN ET AL.: "Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy", THE JOURNAL OF PAIN, vol. 15, no. 7, 2014, pages 712 - 725, XP055331011, ISSN: 1526-5900
CHONG, ALBERT J. ET AL.: "Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart", THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol. 128, no. 2, 2004, pages 170 - 179, XP004537966, ISSN: 0022-5223
See also references of EP 3296296A4

Attorney, Agent or Firm:

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

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