CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME

Title:

CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2012/144790

Kind Code:

A1

Abstract:

The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.

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Inventors:

KIM JONG WOO (KR)
LEE SANG WOOK (KR)
PARK SANG JIN (KR)
SUH JOO WON (KR)
LEE IN AE (KR)
YOON TAE MI (KR)
CHOI JONG KEUN (KR)
LEE JI EAN (KR)
KIM JIN YONG (KR)
JIN YING YU (KR)
FRANZBLAU SCOTT (US)
CHO SANGHYUN (US)
GAO WEI (US)
PAULI GUIDO (US)
MCALPINE JAMES (US)
NAPOLITANO JOSE (US)
JAKI BIRGIT (US)
FRIESEN BRENT (US)
RODRIGUEZ BRASCO MARIA FLORENCIA (US)
LANKIN DAVID (US)

Application Number:

PCT/KR2012/002933

Publication Date:

October 26, 2012

Filing Date:

April 18, 2012

Export Citation:

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Assignee:

B & C BIOPHARM CO LTD (KR)
MYONGJI UNIV IND & ACAD COOP (KR)
UNIV ILLINOIS (US)
KIM JONG WOO (KR)
LEE SANG WOOK (KR)
PARK SANG JIN (KR)
SUH JOO WON (KR)
LEE IN AE (KR)
YOON TAE MI (KR)
CHOI JONG KEUN (KR)
LEE JI EAN (KR)
KIM JIN YONG (KR)
JIN YING YU (KR)
FRANZBLAU SCOTT (US)
CHO SANGHYUN (US)
GAO WEI (US)
PAULI GUIDO (US)
MCALPINE JAMES (US)
NAPOLITANO JOSE (US)
JAKI BIRGIT (US)
FRIESEN BRENT (US)
RODRIGUEZ BRASCO MARIA FLORENCIA (US)
LANKIN DAVID (US)

International Classes:

C07K7/64

Domestic Patent References:

WO2009119710A1	2009-10-01
WO2009119710A1	2009-10-01

Foreign References:

US20100093615A1	2010-04-15
US20100093615A1	2010-04-15

Other References:

TERUI Y ET AL.: "New cyclictetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).", BIOORG MED CHEM LETT., vol. 18, no. 24, 15 December 2008 (2008-12-15), pages 6321 - 3, XP025679019
See also references of EP 2699584A4
WHO: "Actions For Life - Towards a world free of tuberculosis", 2006, WORLD HEALTH ORGANIZATION
WHO ANTI-TUBERCULOSIS DRUG RESISTANCE IN THE WORLD, 2008
KOENIG, R.: "Drug-resistant tuberculosis. In South Africa, XDR TB and HIV prove a deadly combination", SCIENCE, vol. 319, 2008, pages 894 - 897
WHO: "Global tuberculosis control: a short update to the 2009 report", 2009, WORLD HEALTH ORGANIZATION
TERUI ET AL., BIOORG. MED. CHEM. LETT., vol. 18, no. 24, 2008, pages 6321 - 3

Attorney, Agent or Firm:

BAE, KIM & LEE IP GROUP (Shinduk Bldg.1329-7 Seocho 2-dong, Seocho-gu, Seoul 137-858, KR)

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