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Title:
CYCLOBUTANE DICARBOXYLIC ACID PLATINUM COMPLEX AND INTERMEDIARY, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/165964
Kind Code:
A1
Abstract:
A cyclobutane dicarboxylic acid platinum complex shown in formula (I) and an intermediary, a preparation method, a pharmaceutical composition, and a use thereof. The cyclobutane dicarboxylic acid platinum complex has good anti-tumour activity. The complex provided in the present invention has a water solubility several dozen times higher than existing platinum anti-tumour drugs; the feature of high water solubility can increase and improve the excretion of drugs in the kidneys and alleviate the high renal toxicity side effects normally present for platinum drugs; the compounds are easily formulated and more convenient for clinical application.

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Inventors:
GAO, Xiangqian (No. 725, Block B No. 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 4, 300384, CN)
HAN, Jianbin (No. 725, Block B No. 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 4, 300384, CN)
YANG, Jinna (No. 725, Block B No. 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 4, 300384, CN)
YANG, Liu (No. 725, Block B No. 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 4, 300384, CN)
Application Number:
CN2019/076236
Publication Date:
September 06, 2019
Filing Date:
February 27, 2019
Export Citation:
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Assignee:
GUDUI BIOPHARMA TECHNOLOGY INC. (No. 725, Block B No. 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 4, 300384, CN)
International Classes:
C07F15/00; A61K31/282; A61P35/00
Domestic Patent References:
WO2008086783A22008-07-24
Foreign References:
CN106608898A2017-05-03
CN102276657A2011-12-14
CN102276656A2011-12-14
Attorney, Agent or Firm:
BEIJING TANLULAI PATENT AGENT LTD (Suite 312, 3F Building No.10, Xinxingdongxiang No.15, Xicheng District, Beijing 4, 100044, CN)
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