Title:
CYTARABINE PRODRUG NUCLEOSIDE CYCLIC PHOSPHATE COMPOUND BASED ON LIVER-SPECIFIC DELIVERY AND USE
Document Type and Number:
WIPO Patent Application WO/2019/120300
Kind Code:
A1
Abstract:
Disclosed are an anticancer prodrug nucleoside cyclic phosphate compound based on liver-specific delivery (LSD) technology and the use thereof, in particular, provided are a compound of formula (I) and an isomer, a pharmaceutically acceptable salt, a hydrate, a solvate and a corresponding pharmaceutical composition thereof, and the use of the compound alone or in combination with other anticancer drugs against cancer, especially in treating hepatic carcinoma (HCC).
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Inventors:
XI ZHIJIAN (CN)
XU HUAQIANG (CN)
LU CHUNPING (CN)
WU ZHONGSHAN (CN)
XU HUAQIANG (CN)
LU CHUNPING (CN)
WU ZHONGSHAN (CN)
Application Number:
PCT/CN2018/122822
Publication Date:
June 27, 2019
Filing Date:
December 21, 2018
Export Citation:
Assignee:
ZHEJIANG PALO ALTO PHARMACEUTICALS INC (CN)
International Classes:
C07F9/6574; A61K31/7052; A61P35/00; C07H19/04
Domestic Patent References:
| WO2004041834A2 | 2004-05-21 | |||
| WO2007022073A2 | 2007-02-22 |
Foreign References:
| CN102164939A | 2011-08-24 |
Other References:
BOYER, SERGE H.: "Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1- P -D-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma", J. MED. CHEM., vol. 49, no. 26, 21 December 2006 (2006-12-21), pages 771 - 7720, XP055669950
ERION, MARK D.: "Design, Synthesis, and Characterization of a Series of Cytochrome P450 3A-Activated Prodrugs(HepDirect Prodrugs) Useful for Targe- ting Phosph(on)ate-Based Drugs to the Liver", J. AM. CHEM. SOC., vol. 126, no. 16, 2 April 2004 (2004-04-02), pages 5154 - 63, XP002628532
CARROLL, STEVEN S.: "Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2'-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 55, no. 8, 31 May 2011 (2011-05-31), pages 3854 - 60, XP055621096
See also references of EP 3730504A4
ERION, MARK D.: "Design, Synthesis, and Characterization of a Series of Cytochrome P450 3A-Activated Prodrugs(HepDirect Prodrugs) Useful for Targe- ting Phosph(on)ate-Based Drugs to the Liver", J. AM. CHEM. SOC., vol. 126, no. 16, 2 April 2004 (2004-04-02), pages 5154 - 63, XP002628532
CARROLL, STEVEN S.: "Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2'-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 55, no. 8, 31 May 2011 (2011-05-31), pages 3854 - 60, XP055621096
See also references of EP 3730504A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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