Title:
DANTROLENE AQUEOUS FORMULATION AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2021/044608
Kind Code:
A1
Abstract:
As a technique for suppressing the generation of impurities in an aqueous formulation of dantrolene or a pharmacologically acceptable salt thereof, there is provided a dantrolene aqueous formulation including dantrolene or a pharmacologically acceptable salt thereof and mannitol, wherein the dantrolene aqueous formulation comprises a first agent including a dry powder of dantrolene or a pharmacologically acceptable salt thereof, and a second agent composed of an aqueous composition including mannitol, the first agent and the second agent being prepared at the time of use.
Inventors:
KAWASHIMA HIROYUKI (JP)
TAKASU MASAHIRO (JP)
CHEN YI-LIN (TW)
LIU YU-SHENG (TW)
TAKASU MASAHIRO (JP)
CHEN YI-LIN (TW)
LIU YU-SHENG (TW)
Application Number:
PCT/JP2019/035122
Publication Date:
March 11, 2021
Filing Date:
September 06, 2019
Export Citation:
Assignee:
CMIC HOLDINGS CO LTD (JP)
ORPHANPACIFIC INC (JP)
ORPHANPACIFIC INC (JP)
International Classes:
A61K31/4178; A61K9/08; A61K9/19; A61K47/26; A61K47/40; A61P21/02
Foreign References:
| JP2018531268A | 2018-10-25 | |||
| JP2019505571A | 2019-02-28 |
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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