DEFINED MULTI-CONJUGATE OLIGONUCLEOTIDES

WIPO Patent Application WO/2016/205410

A3

Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or to produce new or altered phenotypes in cells or organisms.

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HADWIGER PHILIPP (DE)
VORNLOCHER HANS-PETER (DE)
BROWN JONATHAN MILES (US)
DAHLMAN JAMES EVERETT (US)
NEUMAN KRISTIN K H (US)

PCT/US2016/037685

February 09, 2017

June 15, 2016

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MPEG LA LLC (US)

C12N15/11

US20080311040A1	2008-12-18
US20140309281A1	2014-10-16

MOK ET AL.: "Multimeric small Interfering ribonucleic acid for highly efficient sequence-specific gene silencing", NATURE MATERIALS, vol. 9, March 2010 (2010-03-01), pages 272 - 278, XP055068639
LEE ET AL.: "Small-Interfering RNA (siRNA)-Based Functional Micro- and Nanostructures for Efficient and Selective Gene Silencing", ACCOUNTS OF CHEMICAL RESEARCH, vol. 45, no. 7, 13 March 2012 (2012-03-13), pages 1014 - 1025, XP055362866

HUBNER, Isaac, A. et al. (US)

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