Title:
DELIVERY OF AGENTS USING INTERFERING NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2011/116152
Kind Code:
A3
Abstract:
Provided are compositions and methods for delivery of therapeutic agents, such as chemically stabilized antisense oligonucleotides useful in RNA silencing. The compositions include interfering nanoparticles (iNOPs) associated with one or more agents. Several functional iNOP derivatives are provided which allow for targeted delivery of agents to specific cell types as well as exhibiting reduced cellular toxicity.
Inventors:
RANA TARIQ M (US)
Application Number:
PCT/US2011/028748
Publication Date:
April 05, 2012
Filing Date:
March 16, 2011
Export Citation:
Assignee:
SANFORD BURNHAM MED RES INST (US)
RANA TARIQ M (US)
RANA TARIQ M (US)
International Classes:
A61K9/16; A61K31/4164; A61K31/4188; A61K31/70; A61K31/7016; A61K31/7088; A61K31/7105; A61K47/48
Domestic Patent References:
| WO2008151022A2 | 2008-12-11 |
Foreign References:
| KR100909786B1 | 2009-07-29 | |||
| US7514099B2 | 2009-04-07 |
Other References:
CURRENT DRUG TARGETS, vol. 11, no. 6, 2010, pages 699 - 707
Attorney, Agent or Firm:
HAILE, Lisa, A. (4365 Executive Drive Suite 110, San Diego CA, US)
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