Title:
DENGUE VIRUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2020/184730
Kind Code:
A1
Abstract:
The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.
More Like This:
Inventors:
KOHARA MICHINORI (JP)
YASUI FUMIHIKO (JP)
YAMANE DAISUKE (JP)
KOHARA KYOKO (JP)
MORITA KOUICHI (JP)
YASUTOMI YASUHIRO (JP)
ISHII KOJI (JP)
YASUI FUMIHIKO (JP)
YAMANE DAISUKE (JP)
KOHARA KYOKO (JP)
MORITA KOUICHI (JP)
YASUTOMI YASUHIRO (JP)
ISHII KOJI (JP)
Application Number:
PCT/JP2020/012569
Publication Date:
September 17, 2020
Filing Date:
March 13, 2020
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
UNIV KAGOSHIMA (JP)
UNIV NAGASAKI (JP)
UNIV KAGOSHIMA (JP)
UNIV NAGASAKI (JP)
International Classes:
A61K39/12; A61P31/14; A61P37/04; C12N7/01; C12N15/40; C12N15/863
Domestic Patent References:
| WO2006013815A1 | 2006-02-09 |
Foreign References:
| JP2005511042A | 2005-04-28 | |||
| JP2005525821A | 2005-09-02 | |||
| JPH03503364A | 1991-08-01 | |||
| JP2013048597A | 2013-03-14 | |||
| JP2019047582A | 2019-03-22 |
Other References:
FALGOUT, B. ET AL.: "Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis", JOURNAL OF VIROLOGY, vol. 64, no. 9, 1990, pages 4356 - 4363, XP009015144
SATOSHI SEKIGUCHIKIMINORI KIMURATOMOKO CHIYOTAKAHIRO OHTSUKIYOSHIMI TOBITAYUKO TOKUNAGAFUMIHIKO YASUIKYOKO TSUKIYAMA-KOHARATAKAJI : "Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver", PLOS ONE, vol. 7, no. 12, 2012, pages e51656
TAGAYA ET AL., NATURE, 1961
"GenBank", Database accession no. KC333651.1
KOJI ISHII, VIROLOGY, vol. 302, 2001, pages 433 - 444
JIN-WON YOUNYU-WEN HUNANCY TRICOCHEWOLFRAM PFAHLERMOHAMED TAREK SHATAMARLENE DREUXFRANCOIS-LOIC COSSETANTONELLA FOLGORIDONG-HUN LE: "Evidence for Protection against Chronic Hepatitis C Virus Infection in Chimpanzees by Immunization with Replicating Recombinant Vaccinia Virus", JOURNAL OF VIROLOGY, vol. 82, no. 21, 2008, pages 10896 - 10905
FRANCOIS HABERSETZERGERALDINE HONNETCHRISTINE BAINMARIANNE MAYNARD-MUETVINCENT LEROYJEAN-PIERRE ZARSKICYRILLE FERAYTHOMAS F. BAUME: "A Poxvirus Vaccine Is Safe, Induces T-Cell Responses, and Decreases Viral Load in Patients With Chronic Hepatitis C", GASTROENTEROLOGY, vol. 141, 2011, pages 890 - 899
TAKESHI WADAMICHINORI KOHARAYASUHIRO YASUTOMI: "DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model", VACCINE, vol. 31, no. 50, 2013, pages 5968 - 74, XP028776483, DOI: 10.1016/j.vaccine.2013.10.037
TAKAHIRO OHTSUKIKIMINORI KIMURAYUKO TOKUNAGAKYOKO TSUKIYAMA-KOHARACHISE TATENOYUKIKO HAYASHITSUNEKAZU HISHIMAMICHINORI KOHARA: "M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice", J. VIROLOGY, vol. 90, no. 1, 14 October 2015 (2015-10-14), pages 300 - 7
See also references of EP 3939607A4
SATOSHI SEKIGUCHIKIMINORI KIMURATOMOKO CHIYOTAKAHIRO OHTSUKIYOSHIMI TOBITAYUKO TOKUNAGAFUMIHIKO YASUIKYOKO TSUKIYAMA-KOHARATAKAJI : "Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver", PLOS ONE, vol. 7, no. 12, 2012, pages e51656
TAGAYA ET AL., NATURE, 1961
"GenBank", Database accession no. KC333651.1
KOJI ISHII, VIROLOGY, vol. 302, 2001, pages 433 - 444
JIN-WON YOUNYU-WEN HUNANCY TRICOCHEWOLFRAM PFAHLERMOHAMED TAREK SHATAMARLENE DREUXFRANCOIS-LOIC COSSETANTONELLA FOLGORIDONG-HUN LE: "Evidence for Protection against Chronic Hepatitis C Virus Infection in Chimpanzees by Immunization with Replicating Recombinant Vaccinia Virus", JOURNAL OF VIROLOGY, vol. 82, no. 21, 2008, pages 10896 - 10905
FRANCOIS HABERSETZERGERALDINE HONNETCHRISTINE BAINMARIANNE MAYNARD-MUETVINCENT LEROYJEAN-PIERRE ZARSKICYRILLE FERAYTHOMAS F. BAUME: "A Poxvirus Vaccine Is Safe, Induces T-Cell Responses, and Decreases Viral Load in Patients With Chronic Hepatitis C", GASTROENTEROLOGY, vol. 141, 2011, pages 890 - 899
TAKESHI WADAMICHINORI KOHARAYASUHIRO YASUTOMI: "DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model", VACCINE, vol. 31, no. 50, 2013, pages 5968 - 74, XP028776483, DOI: 10.1016/j.vaccine.2013.10.037
TAKAHIRO OHTSUKIKIMINORI KIMURAYUKO TOKUNAGAKYOKO TSUKIYAMA-KOHARACHISE TATENOYUKIKO HAYASHITSUNEKAZU HISHIMAMICHINORI KOHARA: "M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice", J. VIROLOGY, vol. 90, no. 1, 14 October 2015 (2015-10-14), pages 300 - 7
See also references of EP 3939607A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Download PDF: