Title:
PHARMACEUTICAL COMPOSITION FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2020/184729
Kind Code:
A1
Abstract:
The present invention pertains to a pharmaceutical composition for treating amyotrophic lateral sclerosis. More specifically, the present invention pertains to a pharmaceutical composition that is for treating amyotrophic lateral sclerosis and that is characterized by containing mesenchymal stem cells and being administered intravenously.
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Inventors:
HONMOU OSAMU (JP)
SASAKI MASANORI (JP)
SASAKI YUKO (JP)
OKA SHINICHI (JP)
NAKAZAKI MASAHITO (JP)
MAEZAWA RIE (JP)
SASAKI MASANORI (JP)
SASAKI YUKO (JP)
OKA SHINICHI (JP)
NAKAZAKI MASAHITO (JP)
MAEZAWA RIE (JP)
Application Number:
PCT/JP2020/012566
Publication Date:
September 17, 2020
Filing Date:
March 13, 2020
Export Citation:
Assignee:
UNIV SAPPORO MEDICAL (JP)
NIPRO CORP (JP)
NIPRO CORP (JP)
International Classes:
A61P21/02; A61K35/15; A61K35/28
Domestic Patent References:
| WO2009034708A1 | 2009-03-19 | |||
| WO2017188457A1 | 2017-11-02 | |||
| WO2018034023A1 | 2018-02-22 | |||
| WO2009034708A1 | 2009-03-19 | |||
| WO2017188457A1 | 2017-11-02 | |||
| WO2018034023A1 | 2018-02-22 | |||
| WO2014024183A1 | 2014-02-13 | |||
| WO2013082543A1 | 2013-06-06 | |||
| WO2009002503A1 | 2008-12-31 |
Foreign References:
| JP2015531594A | 2015-11-05 | |||
| JP2019046572A | 2019-03-22 | |||
| JP2018138044W | ||||
| JP2018027954A | 2018-02-22 |
Other References:
UCCELLI ANTONIO, MILANESE MARCO, PRINCIPATO MARIA CRISTINA, MORANDO SARA, BONIFACINO TIZIANA, VERGANI LAURA, GIUNTI DEBORA, VOCI A: "Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis", MOLECULAR MEDICINE, vol. 18, 2012, pages 794 - 804, XP055740584, ISSN: 1528-3658, Retrieved from the Internet
SUN, H. ET AL.: "Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model", CELL AND TISSUE RESEARCH, vol. 357, no. 3, 2014, pages 571 - 582, XP035381819, ISSN: 1432-0878, Retrieved from the Internet DOI: 10.1007/s00441-014-1903-z
GUGLIANDOLO AGNESE, BRAMANTI PLACIDO, MAZZON EMANUELA: "Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?", STEM CELLS INTERNATIONAL, vol. 2019, 10 March 2019 (2019-03-10), pages 1 - 16, XP055740588, ISSN: 1687-966X
BURSCH FRANZISKA, RATH KLAUS JAN, SARIKIDI ANASTASIA, BÖSELT SEBASTIAN, KEFALAKES EKATERINI, OSMANOVIC ALMA, THAU‐HABERMANN NADINE: "Analysis of the therapeutic potential of different administration routes and frequencies of human mesenchymal stromal cells in the SODl-G93A-mouse model of amyotrophic lateral sclerosis", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 13, no. 4, February 2019 (2019-02-01), pages 649 - 663, XP055740591
CIERVO YURI, NING KE, JUN XU, SHAW PAMELA J., MEAD RICHARD J.: "Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis", MOLECULAR NEURODEGENERATION, vol. 12, no. 1, 2017, pages 1 - 22, XP055740593, ISSN: 1750-1326
WINKLER ET AL., PROC. NATL. ACAD. SCI., vol. 111, no. 11, 2014, pages E1035 - E1042
WINKLER ET AL., ACTA NEUROPATHOLOGICA, vol. 125, no. 1, 2013, pages 120
NICAISE ET AL., BRAIN RES., vol. 1301, 2009, pages 152 - 162
SASAKI ET AL., NEUROPATHOLOGY, vol. 35, no. 6, 2015, pages 518 - 528
KOSUGE ET AL., NEUROSCI. LETTERS, vol. 454, no. 2, 2009, pages 165 - 169
HORITA ET AL., J. NEUROSCI, RES., vol. 84, no. 7, 2006, pages 1495 - 1504
KIM S ET AL., BRAIN RES, vol. 1123, 2006, pages 27 - 33
UKAI R ET AL., J. NEUROTRAUMA., vol. 24, 2007, pages 508 - 520
See also references of EP 3939660A4
SUN, H. ET AL.: "Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model", CELL AND TISSUE RESEARCH, vol. 357, no. 3, 2014, pages 571 - 582, XP035381819, ISSN: 1432-0878, Retrieved from the Internet
GUGLIANDOLO AGNESE, BRAMANTI PLACIDO, MAZZON EMANUELA: "Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?", STEM CELLS INTERNATIONAL, vol. 2019, 10 March 2019 (2019-03-10), pages 1 - 16, XP055740588, ISSN: 1687-966X
BURSCH FRANZISKA, RATH KLAUS JAN, SARIKIDI ANASTASIA, BÖSELT SEBASTIAN, KEFALAKES EKATERINI, OSMANOVIC ALMA, THAU‐HABERMANN NADINE: "Analysis of the therapeutic potential of different administration routes and frequencies of human mesenchymal stromal cells in the SODl-G93A-mouse model of amyotrophic lateral sclerosis", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 13, no. 4, February 2019 (2019-02-01), pages 649 - 663, XP055740591
CIERVO YURI, NING KE, JUN XU, SHAW PAMELA J., MEAD RICHARD J.: "Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis", MOLECULAR NEURODEGENERATION, vol. 12, no. 1, 2017, pages 1 - 22, XP055740593, ISSN: 1750-1326
WINKLER ET AL., PROC. NATL. ACAD. SCI., vol. 111, no. 11, 2014, pages E1035 - E1042
WINKLER ET AL., ACTA NEUROPATHOLOGICA, vol. 125, no. 1, 2013, pages 120
NICAISE ET AL., BRAIN RES., vol. 1301, 2009, pages 152 - 162
SASAKI ET AL., NEUROPATHOLOGY, vol. 35, no. 6, 2015, pages 518 - 528
KOSUGE ET AL., NEUROSCI. LETTERS, vol. 454, no. 2, 2009, pages 165 - 169
HORITA ET AL., J. NEUROSCI, RES., vol. 84, no. 7, 2006, pages 1495 - 1504
KIM S ET AL., BRAIN RES, vol. 1123, 2006, pages 27 - 33
UKAI R ET AL., J. NEUROTRAUMA., vol. 24, 2007, pages 508 - 520
See also references of EP 3939660A4
Attorney, Agent or Firm:
UMEDA, Shinsuke et al. (JP)
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