Title:
DEUTERATED COMPOUNDS USEFUL AS KRAS G12D INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/262838
Kind Code:
A1
Abstract:
Provided are deuterated compounds of Formula (I), or Formula (I'), or a salt thereof, wherein at least one of R 1 to R 6 is D (Deuterium atom), and X 0, Y, and R is defined herein. Also provided are methods of using such compounds to modulate or inhibit the activity of KRAS G12D mutant protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of various diseases or conditions, such as cancer.
Inventors:
FANG HAIQUAN (AM)
LIU XIAOLEI (CN)
YANG HUI (CN)
LIU XIAOLEI (CN)
YANG HUI (CN)
Application Number:
PCT/CN2022/099362
Publication Date:
December 22, 2022
Filing Date:
June 17, 2022
Export Citation:
Assignee:
SILEXON AI TECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/407; A61K31/4995; A61K31/519; C07D209/00; C07D487/08; C07D519/00
Domestic Patent References:
| WO2022015375A1 | 2022-01-20 | |||
| WO2021041671A1 | 2021-03-04 | |||
| WO2021068898A1 | 2021-04-15 | |||
| WO2021078285A1 | 2021-04-29 | |||
| WO2021088938A1 | 2021-05-14 | |||
| WO2021107160A1 | 2021-06-03 |
Other References:
ZHANG, YINSHENG: "Development of Deuterated Drugs: Past, Present and Future", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 41, no. 12, 31 December 2017 (2017-12-31), pages 902 - 918, XP009521674
Attorney, Agent or Firm:
BEIJING HUIZE INTELLECTUAL PROPERTY LAW LLC (CN)
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