DEUTERATED HPK1 KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

DEUTERATED HPK1 KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/089225

Kind Code:

A1

Abstract:

Provided in the present invention are a compound of general formula I or a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug and a solvate thereof, a preparation method therefor and the use thereof, and in particular, the use of the compound of general formula I or the pharmaceutically acceptable salt, the stereoisomer, the ester, the prodrug and the solvate thereof as an HPK1 kinase inhibitor in the prevention and/or treatment of tumors and diseases caused by or associated with pathogen infection. The above-mentioned compound of general formula I contains at least one deuterium atom, and has high stability and good bioavailability in an animal body.

Inventors:

LIN XINGYU (CN)
LU TINGTING (CN)

Application Number:

PCT/CN2021/124144

Publication Date:

May 05, 2022

Filing Date:

October 15, 2021

Export Citation:

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Assignee:

ZHUHAI YUFAN BIOTECHNOLOGIES CO LTD (CN)

International Classes:

C07D417/14; A61K31/4427; A61K31/4433; A61K31/444; A61K31/4523; A61K31/4545; A61K31/496; A61K31/497; A61K31/551; A61P35/00; A61P35/02; C07D401/14; C07D405/14; C07D417/04

Domestic Patent References:

WO2006021884A2

2006-03-02

Foreign References:

CN110396087A	2019-11-01
CN1777427A	2006-05-24
US20160158360A1	2016-06-09
CN110396087A	2019-11-01

Other References:

S SAWASDIKOSOL: "HPK1 as a novel target for cancer immunotherapy", IMMUNOL RES,, vol. 54, 2012, pages 262 - 265, XP035126315, DOI: 10.1007/s12026-012-8319-1
WADA, E, SEIKAGAKU, vol. 66, 1994, pages 15
GANNES, LZ, COMP BIOCHEM PHYSIOL MOL INTEGR PHYSIOL, vol. 119, 1998, pages 725
See also references of EP 4223752A4

Attorney, Agent or Firm:

BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)

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