Title:
DEVELOPMENT AND USE OF FUNCTION-ENHANCED ANTIBODY BLOCKING AGENT
Document Type and Number:
WIPO Patent Application WO/2022/143951
Kind Code:
A1
Abstract:
Provided is an antibody binding to CD70, or antigen-binding portion thereof, comprising heavy chain CDRs selected from the group consisting of amino acid sequences SEQ ID NOs: 5, 6, 7, 15, 16, 22, 29, 30, 31, 37, 38, 44, 45, 46, 54, 55, 56, 64, 65, 77, 83, 84, 85, 91, 97, 98, 106, 107, 114, 115, 116, 124, 131, 132, 135, 142, 160 or any variant thereof, and/or light chain CDRs selected from the group consisting of amino acid sequences SEQ ID NOs: 10, 11, 12, 19, 25, 26, 34, 41, 49, 50, 51, 59, 60, 61, 68, 69, 74, 80, 88, 101, 102, 103, 110, 111, 119, 120, 121, 127, 128 or any variant thereof, which can block CD70-CD27 interaction and downstream signal conduction, and inhibit tumors. Also provided is a malignant tumor therapeutic agent containing the CD70 antibody, or antigen-binding portion thereof.
Inventors:
XU GANG (CN)
CHEN BO (CN)
WANG CHANGYU (CN)
YU JUNTAO (CN)
CHEN BO (CN)
WANG CHANGYU (CN)
YU JUNTAO (CN)
Application Number:
PCT/CN2021/143371
Publication Date:
July 07, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
KEYMED BIOSCIENCES CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P31/12; A61P35/00; A61P37/06; C07K16/46; C07K19/00; C12N15/13; C12N15/63
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Other References:
"Genbank", Database accession no. NP 035747
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SMITH ET AL., J.CLIN.PATHOL., vol. 57, 2004, pages 912 - 917
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BLAUGSEYMOUR: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING COMPANY
"Remington's Pharmaceutical Sciences: The Science And Practice Of Pharmacy", 1995, MACK PUB. CO.
MARASCO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 7889 - 7893
CARRILLO, H.LIPMAN, D., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
SMITH ET AL., J.CLIN.PATHOL., vol. 57, 2004, pages 912 - 917
NELSON ET AL., J CLIN PATHOL, vol. 53, 2000, pages 111 - 117
BRUMMELL ET AL., BIOCHEM., vol. 32, 1993, pages 1180 - 1187
KOBAYASHI ET AL., PROTEIN ENG., vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC.NATL.ACAD.SCI.USA, vol. 94, 1997, pages 412 - 417
TARABAN, J.IMMUNOL., vol. 173, 2004, pages 6542 - 6
MATTER ET AL., J EXP MED, vol. 203, 2006, pages 2145 - 55
HARTLEY J.A, CANCER RES, vol. 70, no. 17, 2010, pages 6849 - 6858
ANTONOW D. ET AL., CANCER J, vol. 14, no. 3, 2008, pages 154 - 169
HOWARD P.W. ET AL., BIOORG MED CHEM LETT, vol. 19, 2009, pages 6463 - 6466
SAGNOU ET AL., BIOORG MEDCHEM LETT, vol. 10, no. 18, 2000, pages 2083 - 2086
BLAUGSEYMOUR: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING COMPANY
"Remington's Pharmaceutical Sciences: The Science And Practice Of Pharmacy", 1995, MACK PUB. CO.
MARASCO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 7889 - 7893
Attorney, Agent or Firm:
MERITS & TREE (CN)
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