Title:
A DI(4-CHLORO-PHENYLDIGUANIDO) DERIVATIVE WHICH IS FREE OF POTENTIAL GENOTOXICITY AND A PROCESS FOR REDUCING THE RESIDUAL AMOUNT OF P-CHLOROANILINE IN SAID DI(4-CHLORO-PHENYLDIGUANIDO) DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/061272
Kind Code:
A3
Abstract:
The invention relates to a process for reducing the residual amount of p-chloroaniline in chlorhexidine. Also, the invention relates to a process for preparing chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. In addition, the invention refers to the said chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. Further, the invention relates to an analytical HPLC method for the determination of potentially genotoxic impurities in samples of chlorhexidine, or of a pharmaceutically acceptable salt thereof. The invention also relates to stabilized chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution, and to a method for stabilizing chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution.
Inventors:
SANCHEZ SALGUERO LAURA (ES)
BOU BOSCH RAQUEL (ES)
BOSCH I LLADO JORDI (ES)
CAMACHO CARRASCO ANTONIO (ES)
DURAN LOPEZ ERNESTO (ES)
ANDRES MAGNANI PABLO (ES)
BOU BOSCH RAQUEL (ES)
BOSCH I LLADO JORDI (ES)
CAMACHO CARRASCO ANTONIO (ES)
DURAN LOPEZ ERNESTO (ES)
ANDRES MAGNANI PABLO (ES)
Application Number:
PCT/EP2010/067782
Publication Date:
November 10, 2011
Filing Date:
November 18, 2010
Export Citation:
Assignee:
MEDICHEM SA (ES)
SANCHEZ SALGUERO LAURA (ES)
BOU BOSCH RAQUEL (ES)
BOSCH I LLADO JORDI (ES)
CAMACHO CARRASCO ANTONIO (ES)
DURAN LOPEZ ERNESTO (ES)
ANDRES MAGNANI PABLO (ES)
SANCHEZ SALGUERO LAURA (ES)
BOU BOSCH RAQUEL (ES)
BOSCH I LLADO JORDI (ES)
CAMACHO CARRASCO ANTONIO (ES)
DURAN LOPEZ ERNESTO (ES)
ANDRES MAGNANI PABLO (ES)
International Classes:
C07C279/18; C07C277/08; C07C279/26
Domestic Patent References:
| WO2004000253A1 | 2003-12-31 |
Foreign References:
| US6500466B2 | 2002-12-31 | |||
| GB2053195A | 1981-02-04 | |||
| EP0679390A2 | 1995-11-02 |
Other References:
ROSE F I ET AL: "Bisdiguanides having antibacterial activity", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1956 (1956-01-01), pages 4422 - 4425, XP009102704, ISSN: 0368-1769, DOI: DOI:10.1039/JR9560004422
SANTA CRUZ BIOTECHNOLOGY: "CHLORHEXIDINE DiGLUCONATE Solution: sc-252570", 2007, XP002657576, Retrieved from the Internet [retrieved on 20110825]
SANTA CRUZ BIOTECHNOLOGY: "CHLORHEXIDINE DiGLUCONATE Solution: sc-252570", 2007, XP002657576, Retrieved from the Internet
Attorney, Agent or Firm:
ZBM Patents- Zea, Barlocci & Markvardsen (Pl. Catalunya 1, Barcelona, ES)
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