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Title:
DIAGNOSIS METHOD OF STOMACH CANCER THROUGH BACTERIAL METAGENOME ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/111040
Kind Code:
A1
Abstract:
The present invention relates to a method for providing information about stomach cancer diagnosis through bacterial metagenome analysis and, more particularly, to a method for predicting the risk of onset of stomach cancer and diagnosing stomach cancer by performing bacterial metagenome analysis on genes present in vesicles isolated from subject-derived samples to analyze an increase or decrease in the content of extracellular vesicles derived from specific bacteria. Extracellular vesicles released by bacteria existing in the environment may be absorbed into the human body to have a direct influence on oncogenesis. For stomach cancer, which is very high in incidence rate and mortality in Korea, prevention and early diagnosis through onset prediction is very important. By predicting the risk of onset of stomach cancer through bacterial metagenome analysis in vesicles present in human-derived samples, a stomach cancer risk group can be predicted and diagnosed early according to the present invention, whereby the onset of stomach cancer can be delayed or prevented through proper management, and even after onset early diagnosis can be made to decrease the incidence rate of stomach cancer and to increase a therapeutic effect. In addition, the metagenome analysis allows a patient diagnosed with stomach cancer to avoid exposure to causing factors and thus can improve a clinical outcome of stomach cancer or prevent the recurrence of stomach cancer.

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Inventors:
KIM YOON-KEUN (KR)
JEON SEONG GYU (KR)
Application Number:
PCT/KR2017/014860
Publication Date:
June 21, 2018
Filing Date:
December 15, 2017
Export Citation:
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Assignee:
MD HEALTHCARE INC (KR)
AEON MEDIX INC (KR)
International Classes:
C12Q1/68
Foreign References:
KR20110025603A2011-03-10
KR20160073157A2016-06-24
KR20120132183A2012-12-05
US20130065769A12013-03-14
Other References:
TSENG, CHING-HUNG ET AL.: "Gastric Microbiota and Predicted Gene Functions Are Altered after Subtotal Gastrectomy in Patients with Gastric Cancer", SCIENTIFIC REPORTS, vol. 6, 10 February 2016 (2016-02-10), pages 1 - 8, XP055492905
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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