Title:
DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-LGR7 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2010/074192
Kind Code:
A1
Abstract:
Extensive studies have been made, and it is found that a gene for LGR7 protein as well as the protein are highly expressed in cells in clear cell adenocarcinoma which is one type of ovarian cancer. It is also found that an anti-LGR7 antibody has an antibody-dependent cell-mediated cytotoxic (ADCC) activity and a complement-dependent cell-mediated cytotoxic (CDC) activity against LGR7-expressing cells. Based on these findings, it is found that an anti-LGR7 antibody is useful for the diagnosis, prevention and treatment of primary or metastatic clear cell adenocarcinoma.
Inventors:
ABURATANI HIROYUKI (JP)
UEHARA YURIKO (JP)
FUNAHASHI SHINICHI (JP)
UEHARA YURIKO (JP)
FUNAHASHI SHINICHI (JP)
Application Number:
PCT/JP2009/071524
Publication Date:
July 01, 2010
Filing Date:
December 25, 2009
Export Citation:
Assignee:
UNIV TOKYO (JP)
FORERUNNER PHARMA RES CO LTD (JP)
ABURATANI HIROYUKI (JP)
UEHARA YURIKO (JP)
FUNAHASHI SHINICHI (JP)
FORERUNNER PHARMA RES CO LTD (JP)
ABURATANI HIROYUKI (JP)
UEHARA YURIKO (JP)
FUNAHASHI SHINICHI (JP)
International Classes:
C07K16/30; A61K39/395; A61P35/00; A61P43/00; C12N15/02; C12N15/09; G01N33/53; G01N33/574; C12P21/08
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| WO1999048921A1 | 1999-09-30 | |||
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HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ, SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W, FRITZ HJ, METHODS. ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA, PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 5666
ZOLLER, M. J., SMITH, M., NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487 - 6500
WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
DALBADIE- MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 6413
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC.
METHODS, vol. 31, 2003, pages 232 - 242
NIHON SANFUJINKA GAKKAI-SHI, vol. 57, no. 11, 2005, pages 1711
HSU, S. Y. ET AL., MOLEC. ENDOCR., vol. 14, 2000, pages 1257 - 1271
HSUEH A. J. W. ET AL., JOURNAL OF ENDOCRINOLOGY, vol. 187, 2005, pages 333 - 338
BATHGATE RA. ET AL., PHARMACOL REV, vol. 58, 2006, pages 7 - 31
KEM A. ET AL., ENDOCRINOLOGY, vol. 148, 2007, pages 1181 - 1194
KRISTIANSEN K., PHARMACOLOGY & THERAPEUTICS, vol. 103, 2004, pages 21 - 80
HALLS M. L. ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 150, 2007, pages 677 - 691
VAN DER WESTHUIZEN, E. T. ET AL., CURRENT DRUG TARGETS, vol. 8, 2007, pages 91 - 104
HOMBACH-KLONISCH S. ET AL., AMERICAN JOURNAL OF PATHOLOGY, vol. 169, 2006, pages 617 - 632
VINALL R. L. ET AL., ONCOGENE, vol. 25, 2006, pages 2082 - 2093
SUGIYAMA T ET AL., CANCER, vol. 88, 2000, pages 2584
ENOMOTO T, PROCEEDINGS OF ASCO, 2003, pages 1797
SAMBROOK J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G., MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G., MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
FASEB J, vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
ED HARLOW, DAVID LANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
EBERT, K. M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
CO, M. S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M., HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
PLUECKTHUN, A., SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HOLLINGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
CELLULAR & MOLECULAR IMMUNOLOGY, vol. 3, 2006, pages 439 - 443
HUDSON ET AL., J. IMMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
BETTER, M., HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 476 - 496
PLUCKTHUN, A., SKERRA, A., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS ENZYMOL., vol. 121, 1986, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E., WALKER, B. W., TRENDS BIOTECHNOL., vol. 9, 1991, pages 132 - 137
LANGONE J. J. ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON R. J. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
SIVAM G. ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER A. J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK E. J. ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE V. ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
THORPE P. E. ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK E. J. ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
BOLOGNESI A. ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE F., BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
CASELLAS P. ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
ED HARLOW, DAVID LANE: "Antibodies A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Current Protocols in Immunology", 1993, JOHN WILEY & SONS, INC.
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ, SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W, FRITZ HJ, METHODS. ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA, PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 5666
ZOLLER, M. J., SMITH, M., NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487 - 6500
WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
DALBADIE- MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 6413
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC.
METHODS, vol. 31, 2003, pages 232 - 242
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
Spring water Original aim (JP)
Spring water Original aim (JP)
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