Title:
DIAGNOSTIC METHOD FOR NEPHROTIC SYNDROME, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEPHROTIC SYNDROME, AND METHOD FOR SCREENING THE PROPHYLACTIC OR THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2010/084668
Kind Code:
A1
Abstract:
A single nucleotide polymorphism of a nucleotide located on Glypican-5 gene or a single nucleotide polymorphism of a nucleotide that is in linkage disequilibrium with the aforementioned nucleotide is analyzed, and nephrotic syndrome is diagnosed based on the results of the analysis. The screening for a prophylactic or therapeutic agent for nephrotic syndrome is achieved by selecting a substance that can alter the expression level of Glypican-5. A pharmaceutical preparation for preventing or treating nephrotic syndrome is provided, which comprises a fibroblast growth factor (FGF) signaling inhibitor as an active ingredient.
Inventors:
NOIRI EISEI (JP)
OKAMOTO KOJI (JP)
TOKUNAGA KATSUSHI (JP)
OKAMOTO KOJI (JP)
TOKUNAGA KATSUSHI (JP)
Application Number:
PCT/JP2009/070500
Publication Date:
July 29, 2010
Filing Date:
December 07, 2009
Export Citation:
Assignee:
UNIV TOKYO (JP)
RIKEN (JP)
TOKUSHUKAI (JP)
NOIRI EISEI (JP)
OKAMOTO KOJI (JP)
TOKUNAGA KATSUSHI (JP)
RIKEN (JP)
TOKUSHUKAI (JP)
NOIRI EISEI (JP)
OKAMOTO KOJI (JP)
TOKUNAGA KATSUSHI (JP)
International Classes:
C12Q1/68; A61K31/7105; A61K45/00; A61K48/00; A61P13/12; C12N15/09
Other References:
HATTA HIDEKAZU: "Immunohistochemical analysis of cell cycle for podocyte.", KAWASAKI MEDICAL JOURNAL, vol. 25, no. 3-4, 1999, pages 87 - 98
YAGI MIKIO ET AL.: "Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis.", GENERAL PHARMACOLOGY, vol. 31, no. 5, 1998, pages 765 - 773
MOHAMMADI, MOOSA ET AL.: "Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.", THE EMBO JOURNAL, vol. 17, no. 20, 1998, pages 5896 - 5904
OBEIDOVA, H. ET AL.: "Genetic basis of nephrotic syndrome--review.", PRAGUE MEDICAL REPORT, vol. 107, no. 1, 2006, pages 5 - 16
DATABASE NCBI [online] 25 May 2006 (2006-05-25), "Reference SNP(refSNP) Cluster Report: rs16946160.", retrieved from http://www.ncbi.nlm.nih.gov/ projects/SNP/snp ref.cgi?rs=16946160 Database accession no. rs16946160
LAI, JIN-PING ET AL.: "Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.", HEPATOLOGY, vol. 47, no. 4, 2008, pages 1211 - 1222
YAGI MIKIO ET AL.: "Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis.", GENERAL PHARMACOLOGY, vol. 31, no. 5, 1998, pages 765 - 773
MOHAMMADI, MOOSA ET AL.: "Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.", THE EMBO JOURNAL, vol. 17, no. 20, 1998, pages 5896 - 5904
OBEIDOVA, H. ET AL.: "Genetic basis of nephrotic syndrome--review.", PRAGUE MEDICAL REPORT, vol. 107, no. 1, 2006, pages 5 - 16
DATABASE NCBI [online] 25 May 2006 (2006-05-25), "Reference SNP(refSNP) Cluster Report: rs16946160.", retrieved from http://www.ncbi.nlm.nih.gov/ projects/SNP/snp ref.cgi?rs=16946160 Database accession no. rs16946160
LAI, JIN-PING ET AL.: "Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.", HEPATOLOGY, vol. 47, no. 4, 2008, pages 1211 - 1222
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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