Title:
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH C-C CHEMOKINE RECEPTOR TYPE 6 (CCR6)
Document Type and Number:
WIPO Patent Application WO2005095953
Kind Code:
A3
Abstract:
The invention provides a human CCR6 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, cancer, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, cancer, metabolic diseases, gastroenterological diseases, hematological diseases, respiratory diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR6 as well as pharmaceutical compositions comprising such compounds.
Inventors:
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
Application Number:
PCT/EP2005/001738
Publication Date:
June 22, 2006
Filing Date:
February 19, 2005
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
International Classes:
G01N33/68; A61K38/00; A61K39/00; A61K48/00; C12Q1/68; G01N33/48; G01N33/574
Domestic Patent References:
| WO2002061087A2 | 2002-08-08 | |||
| WO2002026764A2 | 2002-04-04 |
Foreign References:
| US20030153525A1 | 2003-08-14 |
Other References:
WANG JUN ET AL: "Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype.", CANCER RESEARCH, vol. 64, no. 5, 1 March 2004 (2004-03-01), pages 1861 - 1866, XP002349492, ISSN: 0008-5472
EK SARA ET AL: "Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells", CANCER RESEARCH, vol. 62, no. 15, 1 August 2002 (2002-08-01), pages 4398 - 4405, XP002349494, ISSN: 0008-5472
DUERIG J ET AL: "Differential expression of chemokine receptors in B cell malignancies", LEUKEMIA (BASINGSTOKE), vol. 15, no. 5, May 2001 (2001-05-01), pages 752 - 756, XP002349495, ISSN: 0887-6924
HILBIG CLARKE A ET AL: "SELECTIVE COX-2 INHIBITION SUPPRESSES HUMAN GASTRIC CANCER GROWTH THROUGH ALTERATION OF GENES REGULATING IMMUNE RESPONSE, SIGNALING AND DIFFERENTIATION: A DNA ARRAY ANALYSIS OF 8700 GENES.", DIGESTIVE DISEASE WEEK ABSTRACTS AND ITINERARY PLANNER, vol. 2003, 2003, & DIGESTIVE DISEASE 2003; FL, ORLANDO, USA; MAY 17-22, 2003, pages Abstract No. M1019, XP008054228
DELLACASAGRANDE J ET AL: "Liver metastasis of cancer facilitated by chemokine receptor CCR6.", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 57, no. 6, June 2003 (2003-06-01), pages 534 - 544, XP008054321, ISSN: 0300-9475
JOHRER K ET AL: "Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma", CLINICAL CANCER RESEARCH 01 APR 2005 UNITED STATES, vol. 11, no. 7, 1 April 2005 (2005-04-01), pages 2459 - 2465, XP008054225, ISSN: 1078-0432
EK SARA ET AL: "Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells", CANCER RESEARCH, vol. 62, no. 15, 1 August 2002 (2002-08-01), pages 4398 - 4405, XP002349494, ISSN: 0008-5472
DUERIG J ET AL: "Differential expression of chemokine receptors in B cell malignancies", LEUKEMIA (BASINGSTOKE), vol. 15, no. 5, May 2001 (2001-05-01), pages 752 - 756, XP002349495, ISSN: 0887-6924
HILBIG CLARKE A ET AL: "SELECTIVE COX-2 INHIBITION SUPPRESSES HUMAN GASTRIC CANCER GROWTH THROUGH ALTERATION OF GENES REGULATING IMMUNE RESPONSE, SIGNALING AND DIFFERENTIATION: A DNA ARRAY ANALYSIS OF 8700 GENES.", DIGESTIVE DISEASE WEEK ABSTRACTS AND ITINERARY PLANNER, vol. 2003, 2003, & DIGESTIVE DISEASE 2003; FL, ORLANDO, USA; MAY 17-22, 2003, pages Abstract No. M1019, XP008054228
DELLACASAGRANDE J ET AL: "Liver metastasis of cancer facilitated by chemokine receptor CCR6.", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 57, no. 6, June 2003 (2003-06-01), pages 534 - 544, XP008054321, ISSN: 0300-9475
JOHRER K ET AL: "Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma", CLINICAL CANCER RESEARCH 01 APR 2005 UNITED STATES, vol. 11, no. 7, 1 April 2005 (2005-04-01), pages 2459 - 2465, XP008054225, ISSN: 1078-0432
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