Title:
DIAMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2003/016302
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (1), salts thereof, solvates of the same or N−oxides of the same: Q1−Q2−T0−N(R1)−Q3−N(R2)−T1−Q4 (1) wherein R1 and R2 represent each hydrogen, etc.&semi Q1 represents optionally substituted, saturated or unsaturated 5− or 6−membered hydrocarbyl, etc.&semi Q2 represents a single bond, etc.&semi Q3 represents the following group&semi (wherein Q5 represents C1−8 alkylene, etc.)&semi and T0 and T1 represent each carbonyl, etc. These compounds are useful as preventives and&sol or remedies for brain infarction, cerebral embolism, myocardial infarction, angina, pulmonary infarction, pulmonary embolism, Buerger’s disease, bottom venous thrombosis, disseminated intravascular coagulation, thrombosis following artificial valve&sol joint replacement, thrombosis and reocclusion following circulation reconstruction, systemic inflammatory responsive syndrome (SIRS), multiple organ dysfunction (MODS), thrombosis in extracorporeal circulation or blood coagulation in collecting blood.
Inventors:
OHTA TOSHIHARU (JP)
KOMORIYA SATOSHI (JP)
YOSHINO TOSHIHARU (JP)
UOTO KOUICHI (JP)
NAKAMOTO YUMI (JP)
NAITO HIROYUKI (JP)
MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)
HAGINOYA NORIYASU (JP)
YOSHIKAWA KENJI (JP)
NAGAMOCHI MASATOSHI (JP)
KOBAYASHI SYOZO (JP)
ONO MAKOTO (JP)
KOMORIYA SATOSHI (JP)
YOSHINO TOSHIHARU (JP)
UOTO KOUICHI (JP)
NAKAMOTO YUMI (JP)
NAITO HIROYUKI (JP)
MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)
HAGINOYA NORIYASU (JP)
YOSHIKAWA KENJI (JP)
NAGAMOCHI MASATOSHI (JP)
KOBAYASHI SYOZO (JP)
ONO MAKOTO (JP)
Application Number:
PCT/JP2002/008119
Publication Date:
February 27, 2003
Filing Date:
August 08, 2002
Export Citation:
Assignee:
DAIICHI SEIYAKU CO (JP)
OHTA TOSHIHARU (JP)
KOMORIYA SATOSHI (JP)
YOSHINO TOSHIHARU (JP)
UOTO KOUICHI (JP)
NAKAMOTO YUMI (JP)
NAITO HIROYUKI (JP)
MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)
HAGINOYA NORIYASU (JP)
YOSHIKAWA KENJI (JP)
NAGAMOCHI MASATOSHI (JP)
KOBAYASHI SYOZO (JP)
ONO MAKOTO (JP)
OHTA TOSHIHARU (JP)
KOMORIYA SATOSHI (JP)
YOSHINO TOSHIHARU (JP)
UOTO KOUICHI (JP)
NAKAMOTO YUMI (JP)
NAITO HIROYUKI (JP)
MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)
HAGINOYA NORIYASU (JP)
YOSHIKAWA KENJI (JP)
NAGAMOCHI MASATOSHI (JP)
KOBAYASHI SYOZO (JP)
ONO MAKOTO (JP)
International Classes:
A61K31/428; A61K31/429; A61K31/437; A61K31/444; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/50; A61K31/501; A61K31/502; A61K31/5025; A61K31/506; A61K31/517; A61K31/519; A61P7/02; A61P9/00; C07D209/42; C07D401/14; C07D417/12; C07D417/14; C07D487/04; C07D401/12; C07D495/04; C07D498/04; C07D513/04; C07D513/14; C07D519/00; C07K5/06; C07K5/08; A61K; A61P; C07D; (IPC1-7): C07D401/12; C07D401/14; C07D417/12; C07D487/04; C07D495/04; C07D498/04; C07D513/04; C07D513/14; C07D519/00; A61K31/428; A61K31/429; A61K31/437; A61K31/444; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/501; A61K31/502; A61K31/5025; A61K31/506; A61K31/517; A61K31/519; A61P7/02; A61P9/00
Domestic Patent References:
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| WO2000064902A2 | 2000-11-02 | |||
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Foreign References:
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Other References:
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TORNEIRO MERCEDES AND STILL CLARK W.: "Simple synthetic receptors that bind peptides in water", TETRAHEDRON, vol. 53, no. 26, 1997, pages 8739 - 8750, XP004106087
THROMBOSIS RESEARCH, vol. 15, 1979, pages 617 - 629
THROMBOSIS RESEARCH, vol. 68, 1992, pages 507 - 512
JOURNAL OF CLINICAL INVESTIGATION, vol. 71, 1983, pages 1383 - 1389
MEBIO, vol. 14, pages 92 - 97
SCIENCE, vol. 248, 1990, pages 593 - 596
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, 1988, pages 10162 - 10167
ORGANIC SYNTHESIS, vol. III, 1995, pages 217
J. ORG. CHEM., vol. 63, 1998, pages 6094
TETRAHEDRON: ASYMMETRY, vol. 7, 1996, pages 843
J. ORG. CHEM., vol. 50, 1985, pages 4154
J. MED. CHEM., vol. 41, 1998, pages 38
J. ORG. CHEM., vol. 61, 1996, pages 8687
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOM, CHUO-KU Tokyo, JP)
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