Title:
DIARYLAMINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/017515
Kind Code:
A1
Abstract:
Provided in the present application are a diarylamine compound, a preparation method therefor and an application thereof. The compound has a structure represented by formula 1; R1 is selected from an alkyl group of C1-12, an alkoxy group of C1-6, a halogen, a haloalkyl group of C1-3, -CN, -NO2, -NH2, a sulfonyl, or an aromatic group; there is more than one R5 and R5 and R2 are selected from hydrogen, an alkyl group of C1-12, an alkoxy group of C1-6, a halogen, a haloalkyl group of C1-3, -CN, -NO2, -NH2, a sulfonyl, or an aromatic group; R3 is selected from a substituted or unsubstituted five-membered or six-membered heterocycle; the Linker is selected from -SO2NR4-, -CONR4- and -NR4-; R4 is selected from hydrogen or an alkyl group of C1-12; and V, W, X, Y, and Z are independently selected from carbon or nitrogen. The diarylamine compound provided in the present application has androgen receptor-inhibiting activity.
Inventors:
HU LAIXING (CN)
WANG TIANQI (CN)
ZHOU JINMING (CN)
LIU YONGHUA (CN)
WU MENG (CN)
LI XIN (CN)
WANG TIANQI (CN)
ZHOU JINMING (CN)
LIU YONGHUA (CN)
WU MENG (CN)
LI XIN (CN)
Application Number:
PCT/CN2021/108229
Publication Date:
January 27, 2022
Filing Date:
July 23, 2021
Export Citation:
Assignee:
INST MED BIOTECHNOLOGY CAMS (CN)
International Classes:
C07D231/12; A61K31/415; A61K31/42; A61K31/426; A61K31/4439; A61P5/26; A61P13/08; A61P15/00; A61P17/00; A61P17/08; A61P17/10; A61P35/00; C07D233/61; C07D261/08; C07D277/28; C07D401/04
Foreign References:
CN111943889A | 2020-11-17 | |||
JP2000109465A | 2000-04-18 | |||
DE10010429A1 | 2001-09-06 | |||
CN106902112A | 2017-06-30 | |||
CN103910679A | 2014-07-09 |
Other References:
FAHIM ASMAA M., MONA A. SHALABY: "Synthesis, Biological Evaluation, Molecular Docking and DFT Calculations of Novel Benzenesulfonamide Derivatives", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER AMSTERDAM, NL, vol. 1176, 27 August 2018 (2018-08-27), NL , pages 408 - 421, XP055889785, ISSN: 0022-2860, DOI: 10.1016/j.molstruc.2018.08.087
DATABASE REGISTRY 29 September 2011 (2011-09-29), ANONYMOUS : "- Benzenesulfonamide, 4-methoxy-N-[5-(4-morpholinyl)-2-pyridinyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Methoxy-N-[5-(4-morpholinyl)-2-pyridinyl]benzenesulfonamide", XP055889828, retrieved from STN Database accession no. 1333978-47-4
DATABASE REGISTRY 14 June 2009 (2009-06-14), ANONYMOUS : "Benzenemethanamine, 4-methoxy-N-[4-(1H-pyrazol-3-yl)phenyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Methoxy-N-[4-(1H-pyrazol-3-yl)phenyl]benzenemethanamine", XP055889831, retrieved from STN Database accession no. 1157160-64-9
DATABASE REGISTRY 18 March 2011 (2011-03-18), ANONYMOUS : " Benzenesulfonamide, 4-nitro-N-[3-(1H-pyrazol-3-yl)phenyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Nitro-N-[3-(1H-pyrazol-3-yl)phenyl]benzenesulfonamide", XP055889833, retrieved from STN Database accession no. 1268828-92-7
DATABASE REGISTRY 29 September 2011 (2011-09-29), ANONYMOUS : "- Benzenesulfonamide, 4-methoxy-N-[5-(4-morpholinyl)-2-pyridinyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Methoxy-N-[5-(4-morpholinyl)-2-pyridinyl]benzenesulfonamide", XP055889828, retrieved from STN Database accession no. 1333978-47-4
DATABASE REGISTRY 14 June 2009 (2009-06-14), ANONYMOUS : "Benzenemethanamine, 4-methoxy-N-[4-(1H-pyrazol-3-yl)phenyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Methoxy-N-[4-(1H-pyrazol-3-yl)phenyl]benzenemethanamine", XP055889831, retrieved from STN Database accession no. 1157160-64-9
DATABASE REGISTRY 18 March 2011 (2011-03-18), ANONYMOUS : " Benzenesulfonamide, 4-nitro-N-[3-(1H-pyrazol-3-yl)phenyl]- (CA INDEX NAME) OTHER CA INDEX NAMES: CN - 4-Nitro-N-[3-(1H-pyrazol-3-yl)phenyl]benzenesulfonamide", XP055889833, retrieved from STN Database accession no. 1268828-92-7
Attorney, Agent or Firm:
LEADER PATENT & TRADEMARK FIRM (CN)
Download PDF: