DIHYDROPYRIDOPHTHALAZINONE COMPOUNDS AS INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR TREATMENT OF DISEASES AND METHOD OF USE THEREOF

Title:

DIHYDROPYRIDOPHTHALAZINONE COMPOUNDS AS INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR TREATMENT OF DISEASES AND METHOD OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/153279

Kind Code:

A1

Abstract:

The present invention provides novel dihydropyridophthalazinone compounds of Formula (I) as PARP inhibitors, and their pharmaceutically acceptable salts, solvates, hydrates, prodrugs and metabolites thereof, the preparation thereof, and the use of such compounds to treat DNA repair dysregulation diseases and conditions such as cancer. The present provides therapeutic applications for the treatment of stroke, myocardial infarction, neurodegenerative diseases, ovarian cancer, breast cancer, prostate cancer, lung cancer, colorectal cancer, and melanoma.

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Inventors:

GUO CHUANGXING (US)
TONG YOUZHI (US)

Application Number:

PCT/CN2018/075907

Publication Date:

August 30, 2018

Filing Date:

February 09, 2018

Export Citation:

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Assignee:

SUZHOU KINTOR PHARMACEUTICALS INC (CN)

International Classes:

C07D237/00; A01N43/58; A61K31/495; A61K31/50; C07D237/26; C07D237/30; C07D471/00; C07D471/04

Domestic Patent References:

WO2013028495A1	2013-02-28
WO2011130661A1	2011-10-20
WO2011097334A1	2011-08-11

Attorney, Agent or Firm:

UNITALEN ATTORNEYS AT LAW (CN)

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