Title:
DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAIING THE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/091202
Kind Code:
A1
Abstract:
Diketohydrazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of having a cysteine protease inhibitory activity, the compounds represented by the general formula (I) are useful as remedies for inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, nerve diseases, liver/biliary duct diseases, bone/joint diseases, metabolic diseases and so on. Because of having an elastase inhibitory activity, these compounds are also useful as remedies for COPD (chronic obstructive pulmonary disease) and so on.
Inventors:
HATAYAMA AKIRA (JP)
TSURUTA HIROSHI (JP)
OCHI YASUO (JP)
IMAWAKA HARUO (JP)
TSURUTA HIROSHI (JP)
OCHI YASUO (JP)
IMAWAKA HARUO (JP)
Application Number:
PCT/JP2003/005252
Publication Date:
November 06, 2003
Filing Date:
April 24, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
HATAYAMA AKIRA (JP)
TSURUTA HIROSHI (JP)
OCHI YASUO (JP)
IMAWAKA HARUO (JP)
HATAYAMA AKIRA (JP)
TSURUTA HIROSHI (JP)
OCHI YASUO (JP)
IMAWAKA HARUO (JP)
International Classes:
A61K31/16; A61K31/165; A61K31/341; A61K31/351; A61K31/40; A61K31/4025; A61K31/4035; A61K31/4152; A61K31/4166; A61K31/4168; A61K31/421; A61K31/423; A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/429; C07C243/34; C07C251/76; C07C251/84; C07C251/86; C07D207/22; C07D207/50; C07D209/46; C07D209/48; C07D211/28; C07D211/72; C07D211/86; C07D211/98; C07D213/70; C07D213/76; C07D213/77; C07D213/78; C07D233/38; C07D233/52; C07D233/80; C07D239/10; C07D239/18; C07D239/36; C07C243/24; C07D241/08; C07D241/18; C07D263/26; C07D263/28; C07D265/08; C07D265/10; C07D265/33; C07D275/02; C07D275/03; C07D275/06; C07D277/18; C07D277/36; C07D277/50; C07D277/54; C07D277/60; C07D277/82; C07D279/02; C07D279/06; C07D279/12; C07D285/10; C07D285/16; C07D309/04; C07D309/28; C07D335/04; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07D513/10; C07F9/59; C07F9/6558; C07D265/32; (IPC1-7): C07C243/24; C07C251/76; C07C251/84; C07C251/86; C07D207/22; C07D207/408; C07D207/50; C07D211/26; C07D213/53; C07D231/08; C07D233/32; C07D263/26; C07D275/02; C07D277/18; C07D307/52; C07D309/04; C07D309/06; C07D405/12; C07D413/12; C07D417/12; C07D487/04; C07D513/10; A61K31/16; A61K31/165; A61K31/341; A61K31/351; A61K31/40; A61K31/4025; A61K31/4035; A61K31/4152; A61K31/4166; A61K31/4168; A61K31/421; A61K31/423; A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/429
Domestic Patent References:
| WO2003013518A1 | 2003-02-20 | |||
| WO1999017775A1 | 1999-04-15 |
Other References:
CROATIA CHEMICA ACTA, vol. 51, no. 1, 1978, pages 81 - 92
See also references of EP 1498411A4
See also references of EP 1498411A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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