Title:
DIPEPTIDE-BASED NEAR-INFRARED IMAGING PROBE FOR TARGETING HEPSIN, AND COMPOSITION FOR NEAR-INFRARED IMAGING FOR METASTATIC CANCER DIAGNOSIS, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METASTATIC CANCER, BOTH COMPOSITIONS COMPRISING PROBE
Document Type and Number:
WIPO Patent Application WO/2020/080593
Kind Code:
A1
Abstract:
The present invention relates to: a near-infrared imaging probe compound for targeting hepsin which is overexpressed in metastatic cancer; and a composition for near-infrared imaging for metastatic cancer diagnosis, and a pharmaceutical composition for preventing and treating metastatic cancer, both compositions comprising the probe. The compound according to the present invention is a fluorescent imaging probe comprising a fluorescent substance such as a BODIPY derivative and Sulfo-Cyanine7 and targeting hepsin, and has excellent heptin inhibitory activity and is confirmed, by cell uptake results, to selectively bind to cells in which hepsin is expressed, thereby enabling the diagnosis, prevention and treatment of carcinoma, such as prostate cancer, in which hepsin is overexpressed at an early stage, and being variously usable in the development of hepsin inhibitors for diagnosing prostate cancer.
Inventors:
BYUN YOUNGJOO (KR)
SON SANG-HYUN (KR)
KIM KYUL (KR)
KWON HONGMOK (KR)
SON SANG-HYUN (KR)
KIM KYUL (KR)
KWON HONGMOK (KR)
Application Number:
PCT/KR2018/013993
Publication Date:
April 23, 2020
Filing Date:
November 15, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUSINESS FOUNDATION SEJONG CAMPUS (KR)
International Classes:
A61K49/00; A61K31/404; A61K31/69; A61K51/04; A61P35/00; C09K11/06
Foreign References:
| US20060153775A1 | 2006-07-13 | |||
| KR20160127479A | 2016-11-04 | |||
| KR20150077495A | 2015-07-08 |
Other References:
KWON, H. ET AL.: "Structure based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTER, vol. 26, no. 2, 2016, pages 310 - 314, XP029380287, DOI: 10.1016/j.bmcl.2015.12.023
WANG, H. ET AL.: "Chemical cell -surface receptor engineering using affinity guided, multivalent organocatalysts", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 31, 2011, pages 12220 - 12228, XP055238986, DOI: 10.1021/ja204422r
WANG, H. ET AL.: "Chemical cell -surface receptor engineering using affinity guided, multivalent organocatalysts", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 31, 2011, pages 12220 - 12228, XP055238986, DOI: 10.1021/ja204422r
Attorney, Agent or Firm:
JUNG, Eun Youl (KR)
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